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Research Article

Clinical, Epidemiologic, Histopathologic and Molecular Features of an Unexplained Dermopathy

  • Michele L. Pearson,

    Affiliation: Division of TB Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Joseph V. Selby,

    Affiliation: Division of Research, Kaiser Permanente Northern California, Oakland, California, United States of America

    X
  • Kenneth A. Katz,

    Affiliation: HIV, STD, and Hepatitis Branch, Health and Human Services Agency, County of San Diego, San Diego, California, United States of America

    X
  • Virginia Cantrell,

    Affiliation: Division of Research, Kaiser Permanente Northern California, Oakland, California, United States of America

    X
  • Christopher R. Braden,

    Affiliation: Division of Food, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Monica E. Parise,

    Affiliation: Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Christopher D. Paddock,

    Affiliation: Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Michael R. Lewin-Smith,

    Affiliation: Environmental Pathology, Joint Pathology Center, Silver Spring, Maryland, United States of America

    X
  • Victor F. Kalasinsky,

    Affiliation: Office of Research & Development, United States Department of Veterans Affairs, Washington, District of Columbia, United States of America

    X
  • Felicia C. Goldstein,

    Affiliation: Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, United States of America

    X
  • Allen W. Hightower,

    Affiliation: Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Arthur Papier,

    Affiliation: Department of Dermatology, University of Rochester School of Medicine, Rochester, New York, United States of America

    X
  • Brian Lewis,

    Affiliation: Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, United States of America

    X
  • Sarita Motipara,

    Affiliation: Division of Research, Kaiser Permanente Northern California, Oakland, California, United States of America

    X
  • Mark L. Eberhard mail,

    mle1@cdc.gov

    Affiliation: Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • for the Unexplained Dermopathy Study Team

    Additional membership of the Unexplained Dermopathy Study Team is provided in the Acknowledgments.

    X
  • Published: January 25, 2012
  • DOI: 10.1371/journal.pone.0029908

Reader Comments (24)

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I got an interesting email

Posted by BrianWatt on 07 Mar 2012 at 16:32 GMT

So I got an interesting email from a reader who asked two questions:

"Brian, you obviously don't agree with the CDC study, so how do you explain the cellulose? "

Having spent two years researching Morgellons, I have eliminated virtually all suspects from my list, except for a neurotoxin, agrobacterium and the ubiquitous Gluconacetobacter xylinus, which in the microbial world, is nature most prolific cellulose producer. The things it can do, almost defy description. Of course it looks like cellulose, it IS cellulose. What is moving under the patients skin, and breaking through it, in the form of fibers and gelantinous material is.....(drum roll....wait for it...........).....cellulose..... Research Gluconacebacter xylinus, and the fibers and cellulose it can spin, and your jaw will drop.

"Brian do you think Lyme can cause the fiber production and cellulose to come through the skin?"

No i do not. However, I believe it is possible most morgellons patients have Lyme, and the tick itself could have inserted the agrobacterium. (and remember, plant cell walls are like 35% cellulose, cotton as high as 90% cellulose. So plants are prolific, cellulose producers. The connection to lyme to me is not relevant, what is relevant is what is producing the cellulose, and that is either AGROBACTERIUM or the ubiquitous Gluconacetobacter xylinus...this is not rocket science, and it's not supernatural. Something is producing those fibers and gelatninous material through the skin, and it is one of those two things.

I hope this helps everyone.

Brian Watt






No competing interests declared.

RE: I got an interesting email

morgellonsjoe replied to BrianWatt on 07 Mar 2012 at 17:30 GMT

Brian, I have couple of thoughts related to this posting. I wonder if the fibers could be a kind of scabbing of nerve cells. The crawling sensations for me always came towards evening (when air temperatures changed). If the cause of these symptoms is accumulation of inorganic mercury beyond the blood/brain barrier, could the fibers be the result of expansion and contraction? I also wanted to mention research by Dr. Dietrich Klinghardt; some of his studies between mothers and children suggest Lyme may be carried prenatally (mercury is also passed at high levels from mother to fetus). I'd certainly like to see the what you find in your research (contact me via jwkeleher.com). It is high time the suffering ended! Thanks, Joe

No competing interests declared.

RE: RE: I got an interesting email

BrianWatt replied to morgellonsjoe on 12 Mar 2012 at 23:55 GMT

Joe,

Thank you for your post. I believe you are correct about the expansion and contraction, but l lean towards the fact that cellulose can hold dozens of times it's weight in water, causing the expansion and contraction. I could be wrong, and often am, but that is my working theory. Certain polymers spun by certain Acetobacter microbes can hold 50 times their weight in water...

This could (very speculative) account for why the majority of those with Morgellons anecdotally report that their symptoms increase both at night AND more so during full moons. The cellulose is under some level of magnetic influence (just like any water body) and the sensation of movement that increases is possibly both 1) Expansion and contraction...2) responding to lunar phase shifting,. (as any plant or water body would)

With regard to the fibers being scabbing of nerve cells, generally we dont think so, based on microscopic examination and other testing data. It's not impossible, but it looks like this movie won't end up that way.

Where the paradox comes in is that the CDC studies would suggest the fibers and such are benign run of the mill debris..(clothing fiber, cellulose from cotton, keratin, etc) In a way, they might be right, but wrong at the same time. Watch this:

If you take a patient with full blown Morgellons, and use the right technologies, you can see the fibers UNDER intact skin....(!!???)

So let's say we pull one out, either out of intact skin, or out of the inside of a hair follicle (they grow in both, the evidence is irrefutable, the slides are clear, the observations are clear) and find out said fiber is Keratin and Cellulose....how did it get there?....lol...

Now, supportes of the study will say "see, we told you !!".....well, but you dont need a degree in molecular biology to know two things: Humans cannot digest, utilize or process cellulose, and they cannot manufacture it either.....So how did it get there?

Then supporters of the study will say "But it's not bugs, look we have tremendous sympathy for these people but it is not worms, and it's not bugs, we have proved that!!".....I never said it WAS bugs......I said something was moving under the skin, and causing massive number of lesions, and unimaginable discomfort......then tricking the brain into thinking it MIGHT be an infestation, which of course, it is not.....So, the CDC study is RIGHT on one level, but wrong at the same time. Can you see it?

Hope this helps everyone.

Brian Watt.





No competing interests declared.

RE: RE: RE: I got an interesting email

BrianWatt replied to BrianWatt on 13 Mar 2012 at 03:34 GMT

Joe,

The other thing to bear in mind, is that when researchers say they cannot find a pathogen, it depends on how you define a pathogen.

If in the dermal layer there is copious amounts of fibers consisting of cellulose (from some sort of cellulose polymer spinning microbe, say, in the Acetobacer family) OR a more direct form of plant cellulose (agrobacterium) that would, from the perspective of the bodies immune response, constitute a pathogen, and a subsequent cytokine response, which would be in vain, because it cannot break it down. So is that a "pathogen"? Of course.....

Im just sayin.........

Hope this helps everyone.

Brian Watt.

No competing interests declared.

RE: RE: RE: RE: I got an interesting email

csidegalNH replied to BrianWatt on 31 Mar 2012 at 14:54 GMT

Hi Brian,
I wanted to stay in touch with you via MDR but there was a problem accessing the site, did a google search and found you here. I don't want to give my email out here but if at some point you could PM via MDR once it is up again I would like to continue sharing notes because i feel our research is very much in line.

Hi to Joe also.

I will be following the dialogue and will have more to say later on, on how the cellulose fibers are possibly being acquired but first need to go over notes and will get back to the conversation.

No competing interests declared.