Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94

Chihiro Kakiuchi; Shinsuke Ishigaki; Christine M. Oslowski; Sonya G. Fonseca; Tadafumi Kato; Fumihiko Urano

doi:10.1371/journal.pone.0004134

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Research Article

Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94

Chihiro Kakiuchi,

Affiliations Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, RIKEN Brain Science Institute, Wako, Saitama, Japan
⨯
Shinsuke Ishigaki,

Affiliation Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Christine M. Oslowski,

Affiliation Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Sonya G. Fonseca,

Affiliation Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Tadafumi Kato,

Affiliation RIKEN Brain Science Institute, Wako, Saitama, Japan
⨯
Fumihiko Urano

* E-mail: Fumihiko.Urano@umassmed.edu

Affiliations Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯

Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94

Chihiro Kakiuchi,
Shinsuke Ishigaki,
Christine M. Oslowski,
Sonya G. Fonseca,
Tadafumi Kato,
Fumihiko Urano

Published: January 6, 2009
https://doi.org/10.1371/journal.pone.0004134

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Question regarding the WFS/GRP94 Ratio, for the authors.

Posted by kpmitton on 08 Jan 2014 at 17:50 GMT

Is it possible that the ratio does not reflect a change in interaction but instead just more capture of extra free WFS as its expression level elevates?

No competing interests declared.

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Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94

Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94

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Question regarding the WFS/GRP94 Ratio, for the authors.

Posted by kpmitton on 08 Jan 2014 at 17:50 GMT