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Research Article

A Metabolomic Analysis of Omega-3 Fatty Acid-Mediated Attenuation of Western Diet-Induced Nonalcoholic Steatohepatitis in LDLR-/- Mice

  • Christopher M. Depner,

    Affiliations: Nutrition Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

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  • Maret G. Traber,

    Affiliations: Nutrition Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

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  • Gerd Bobe,

    Affiliations: Department of Animal and Rangeland Sciences, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

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  • Elizabeth Kensicki,

    Affiliation: Metabolon, Inc., Durham, North Carolina, United States of America

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  • Kurt M. Bohren,

    Affiliation: United States Department of Agriculture, Agricultural Research Service, Children’s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Ginger Milne,

    Affiliation: Eicosanoid Core Laboratory, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Donald B. Jump mail

    Donald.Jump@oregonstate.edu

    Affiliations: Nutrition Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

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  • Published: December 17, 2013
  • DOI: 10.1371/journal.pone.0083756

Reader Comments (1)

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Two corrections made by the corresponding author (DB Jump):

Posted by DonaldJump on 28 Dec 2013 at 21:01 GMT

There are two corrections:

1. Table 1:

In Table 1, the column headings are properly formated in the online version, but are not properly formated in the PDF version (page 12).

The Column headings should be:

WD + O versus Chow WD + D versus WD + O


2. In the "Limitations and Conclusions" section (page 13, PDF version); last paragraph, second to the last sentence.

The printed version reads:

"Finding that addition of DHA to the WD improves methylglyoxal detoxification is equally novel and opens a new window of DHA regulates carbohydrate metabolism."


The correct version is:

"Finding that addition of DHA to the WD improves methylglyoxal detoxification is equally novel, and reveals a new area of DHA regulation of carbohydrate metabolism."

No competing interests declared.