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Research Article

MicroRNA-145 Is Downregulated in Glial Tumors and Regulates Glioma Cell Migration by Targeting Connective Tissue Growth Factor

  • Hae Kyung Lee equal contributor,

    equal contributor Contributed equally to this work with: Hae Kyung Lee, Ariel Bier

    Affiliation: Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • Ariel Bier equal contributor,

    equal contributor Contributed equally to this work with: Hae Kyung Lee, Ariel Bier

    Affiliation: Everard and Mina Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

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  • Simona Cazacu,

    Affiliation: Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • Susan Finniss,

    Affiliation: Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • Cunli Xiang,

    Affiliation: Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • Hodaya Twito,

    Affiliation: Everard and Mina Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

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  • Laila M. Poisson,

    Affiliation: Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • Tom Mikkelsen,

    Affiliation: Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • Shimon Slavin,

    Affiliation: International Center for Cell Therapy and Cancer Immunotherapy (CTCI), Tel-Aviv, Israel

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  • Elad Jacoby,

    Affiliation: Pediatric Hemato-Oncology, The Edmond and Lilly Safra Children’s Hospital, Sheba Medical Center, Tel-Hashomer and The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

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  • Michal Yalon,

    Affiliation: Pediatric Hemato-Oncology, The Edmond and Lilly Safra Children’s Hospital, Sheba Medical Center, Tel-Hashomer and The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

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  • Amos Toren,

    Affiliation: Pediatric Hemato-Oncology, The Edmond and Lilly Safra Children’s Hospital, Sheba Medical Center, Tel-Hashomer and The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

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  • Sandra A. Rempel,

    Affiliation: Barbara Jane Levy Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • Chaya Brodie mail

    nscha@neuro.hfh.edu

    Affiliations: Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America, Everard and Mina Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

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  • Published: February 04, 2013
  • DOI: 10.1371/journal.pone.0054652

Reader Comments (1)

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gliomas

Posted by finocchiaro on 19 Nov 2013 at 12:53 GMT

We published partially similar data on mir145; see Speranza et al, Oncotarget 2012.

No competing interests declared.