Gr1intCD11b+ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection

Andrés Obregón-Henao; Marcela Henao-Tamayo; Ian M. Orme; Diane J. Ordway

doi:10.1371/journal.pone.0080669

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Open Access

Peer-reviewed

Research Article

Gr1^intCD11b⁺ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection

Andrés Obregón-Henao ,

* E-mail: Andres.Obregon@ColoState.EDU (AOH); D.Ordway@colostate.edu (DJO)

Affiliation Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
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Marcela Henao-Tamayo,

Affiliation Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
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Ian M. Orme,

Affiliation Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
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Diane J. Ordway

* E-mail: Andres.Obregon@ColoState.EDU (AOH); D.Ordway@colostate.edu (DJO)

Affiliation Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
⨯

Gr1^intCD11b⁺ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection

Andrés Obregón-Henao,
Marcela Henao-Tamayo,
Ian M. Orme,
Diane J. Ordway

Published: November 1, 2013
https://doi.org/10.1371/journal.pone.0080669

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no inhibition on CD4 T cell proliferation?

Posted by bbsung on 18 Nov 2013 at 21:03 GMT

the phenotype looks like MDSC, but why these cells didn't show suppression on CD4 function (proliferation) in Figure 7 (more CD11b+GR-1 int, more CD4 proliferation ?)? what's the definition of MDSCs.
can anybody explain to me?

No competing interests declared.

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Gr1^intCD11b⁺ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection

Gr1^intCD11b⁺ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection

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no inhibition on CD4 T cell proliferation?

Posted by bbsung on 18 Nov 2013 at 21:03 GMT