Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

Servio H. Ramirez; Shongshan Fan; Holly Dykstra; Slava Rom; Aaron Mercer; Nancy L. Reichenbach; Larisa Gofman; Yuri Persidsky

doi:10.1371/journal.pone.0055972

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Peer-reviewed

Research Article

Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

Servio H. Ramirez ,

Contributed equally to this work with: Servio H. Ramirez, Shongshan Fan

* E-mail: servio@temple.edu

Affiliations Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Shongshan Fan ,

Contributed equally to this work with: Servio H. Ramirez, Shongshan Fan

Affiliation Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Holly Dykstra,

Affiliation Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Slava Rom,

Affiliation Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Aaron Mercer,

Affiliation Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan United States of America
⨯
Nancy L. Reichenbach,

Affiliation Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Larisa Gofman,

Affiliation Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Yuri Persidsky

Affiliations Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

Servio H. Ramirez,
Shongshan Fan,
Holly Dykstra,
Slava Rom,
Aaron Mercer,
Nancy L. Reichenbach,
Larisa Gofman,
Yuri Persidsky

Published: February 13, 2013
https://doi.org/10.1371/journal.pone.0055972

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Publisher's Note: Error in Figure 1

Posted by PLOS_ONE_Group on 14 Nov 2013 at 00:22 GMT

An error was introduced to Figure 1D during the production process. Lines run through the legend text making it difficult to read. Please see the corrected Figure 1 here: http://www.plosone.org/co...

No competing interests declared.

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Endothelial cells
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Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

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Publisher's Note: Error in Figure 1

Posted by PLOS_ONE_Group on 14 Nov 2013 at 00:22 GMT