ACE Inhibitor and Angiotensin Receptor-II Antagonist Prescribing and Hospital Admissions with Acute Kidney Injury: A Longitudinal Ecological Study

Laurie A. Tomlinson; Gary A. Abel; Afzal N. Chaudhry; Charles R. Tomson; Ian B. Wilkinson; Martin O. Roland; Rupert A. Payne

doi:10.1371/journal.pone.0078465

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Open Access

Peer-reviewed

Research Article

ACE Inhibitor and Angiotensin Receptor-II Antagonist Prescribing and Hospital Admissions with Acute Kidney Injury: A Longitudinal Ecological Study

Laurie A. Tomlinson ,

* E-mail: lat42@cam.ac.uk

Affiliation Cambridge Clinical Trials Unit, University of Cambridge, Cambridge, United Kingdom
⨯
Gary A. Abel,

Affiliation Cambridge Centre for Health Services Research, Institute of Public Health, Cambridge, United Kingdom
⨯
Afzal N. Chaudhry,

Affiliation Department of Nephrology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom
⨯
Charles R. Tomson,

Affiliation The Richard Bright Renal Unit, North Bristol National Health Service Trust, Bristol, United Kingdom
⨯
Ian B. Wilkinson,

Affiliation Cambridge Clinical Trials Unit, University of Cambridge, Cambridge, United Kingdom
⨯
Martin O. Roland,

Affiliation Cambridge Centre for Health Services Research, Institute of Public Health, Cambridge, United Kingdom
⨯
Rupert A. Payne

Affiliation Cambridge Centre for Health Services Research, Institute of Public Health, Cambridge, United Kingdom
⨯

ACE Inhibitor and Angiotensin Receptor-II Antagonist Prescribing and Hospital Admissions with Acute Kidney Injury: A Longitudinal Ecological Study

Laurie A. Tomlinson,
Gary A. Abel,
Afzal N. Chaudhry,
Charles R. Tomson,
Ian B. Wilkinson,
Martin O. Roland,
Rupert A. Payne

Published: November 6, 2013
https://doi.org/10.1371/journal.pone.0078465

Reader Comments

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Interesting

Posted by alan2102 on 08 Nov 2013 at 20:42 GMT

Interesting study, which does not comfortably comport with the evidence favoring renal protective activity of ARBs, particularly telmisartan:

http://www.ncbi.nlm.nih.g...
J Renin Angiotensin Aldosterone Syst. 2006 Dec;7(4):185-91.
Potential protective effects of telmisartan on renal function deterioration.

http://www.ncbi.nlm.nih.g...
J Nephrol. 2011 Sep-Oct;24(5):569-80. doi: 10.5301/JN.2011.6445.
Renal protection with angiotensin receptor blockers: where do we stand.

http://www.ncbi.nlm.nih.g...
J Hypertens. 2006 Jan;24(1):11-25.
Blockade of the renin-angiotensin-aldosterone system: a key therapeutic strategy to reduce renal and cardiovascular events in patients with diabetes.

http://www.ncbi.nlm.nih.g...
Int J Cardiol. 2012 May 3.
Effects of telmisartan on proteinuria or albuminuria: A meta-analysis of randomized trials.

No competing interests declared.

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ACE Inhibitor and Angiotensin Receptor-II Antagonist Prescribing and Hospital Admissions with Acute Kidney Injury: A Longitudinal Ecological Study

ACE Inhibitor and Angiotensin Receptor-II Antagonist Prescribing and Hospital Admissions with Acute Kidney Injury: A Longitudinal Ecological Study

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Interesting

Posted by alan2102 on 08 Nov 2013 at 20:42 GMT