MicroRNA-1280 Inhibits Invasion and Metastasis by Targeting ROCK1 in Bladder Cancer

Shahana Majid; Altaf A. Dar; Sharanjot Saini; Varahram Shahryari; Sumit Arora; Mohd Saif Zaman; Inik Chang; Soichiro Yamamura; Takeshi Chiyomaru; Shinichiro Fukuhara; Yuichiro Tanaka; Guoren Deng; Z. Laura Tabatabai; Rajvir Dahiya

doi:10.1371/journal.pone.0046743

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Open Access

Peer-reviewed

Research Article

MicroRNA-1280 Inhibits Invasion and Metastasis by Targeting ROCK1 in Bladder Cancer

Shahana Majid,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Altaf A. Dar,

Affiliation Research Institute, California Pacific Medical Center, San Francisco, California, United States of America
⨯
Sharanjot Saini,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Varahram Shahryari,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Sumit Arora,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Mohd Saif Zaman,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Inik Chang,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Soichiro Yamamura,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Takeshi Chiyomaru,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Shinichiro Fukuhara,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Yuichiro Tanaka,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Guoren Deng,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Z. Laura Tabatabai,

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯
Rajvir Dahiya

* E-mail: rdahiya@urology.ucsf.edu

Affiliation Department of Urology, VA Medical Center and UCSF, San Francisco, California, United States of America
⨯

MicroRNA-1280 Inhibits Invasion and Metastasis by Targeting ROCK1 in Bladder Cancer

Shahana Majid,
Altaf A. Dar,
Sharanjot Saini,
Varahram Shahryari,
Sumit Arora,
Mohd Saif Zaman,
Inik Chang,
Soichiro Yamamura,
Takeshi Chiyomaru,
Shinichiro Fukuhara

Published: October 4, 2012
https://doi.org/10.1371/journal.pone.0046743

Reader Comments

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Is miRNA, miR-1280 a genuine miRNA or a fragment of a tRNA?

Posted by sssiddiqui on 01 Nov 2013 at 06:39 GMT

Majid et al have very impressive data in the paper about the role of miRNA, miR-1280. However, Sanger institute's database miRDB has declared it a fragment of tRNA, This is highly intriguing as both gain of function and loss of function effect of miR-1280 is very convincing from the paper published by Majid et al. The key questions are, if there is a homology in miR-1280 seed region and the tRNA fragment, or this tRNA may actually be involved in gene regulation?

No competing interests declared.

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MicroRNA-1280 Inhibits Invasion and Metastasis by Targeting ROCK1 in Bladder Cancer

MicroRNA-1280 Inhibits Invasion and Metastasis by Targeting ROCK1 in Bladder Cancer

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Is miRNA, miR-1280 a genuine miRNA or a fragment of a tRNA?

Posted by sssiddiqui on 01 Nov 2013 at 06:39 GMT