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closeRecently derived mouse strains show more typical vertebrate telomere lengths
Posted by pwestep on 31 Dec 2010 at 19:31 GMT
much like that in mice, which also have very long telomeres that do not seem to shorten significantly during life
http://plosone.org/article/info:doi/10.1371/journal.pone.0007688#article1.body1.sec3.p2
Hemann and Greider have shown that only long-established lab strains of mice have long telomeres (Hemann MT and CW Greider. Wild-derived inbred mouse strains have short telomeres. Nucleic Acids Res. 2000; 22: 4474-8.). Recently derived wild mice have telomere lengths much more typical of wild vertebrates (under 20kb) and similar to humans. It is possible that D. rerio has undergone a similar alteration of telomere biology and resulting telomere expansion through many generations of abnormally short breeding cycles.
RE: Recently derived mouse strains show more typical vertebrate telomere lengths
lundx072 replied to pwestep on 31 Dec 2010 at 23:13 GMT
This is quite interesting and could be true. If I ever have access to wild-caught zebrafish, this could be tested.