Drug-Induced Reactivation of Apoptosis Abrogates HIV-1 Infection

Hartmut M. Hanauske-Abel; Deepti Saxena; Paul E. Palumbo; Axel-Rainer Hanauske; Augusto D. Luchessi; Tavane D. Cambiaghi; Mainul Hoque; Michael Spino; Darlene D'Alliessi Gandolfi; Debra S. Heller; Sukhwinder Singh; Myung Hee Park; Bernadette M. Cracchiolo; Fernando Tricta; John Connelly; Anthony M. Popowicz; Richard A. Cone; Bart Holland; Tsafi Pe’ery; Michael B. Mathews

doi:10.1371/journal.pone.0074414

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Peer-reviewed

Research Article

Drug-Induced Reactivation of Apoptosis Abrogates HIV-1 Infection

Hartmut M. Hanauske-Abel ,

* E-mail: hanaushm@njms.rutgers.edu (HMH); mathews@njms.rutgers.edu (MBM)

Affiliations Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America, Department of Pediatrics, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America, Department of Obstetrics, Gynecology & Women’s Health, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
Deepti Saxena,

Current address: Section of Infectious Diseases and International Health, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Affiliation Department of Pediatrics, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
Paul E. Palumbo,

Current address: Section of Infectious Diseases and International Health, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Affiliation Department of Pediatrics, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
Axel-Rainer Hanauske,

Current address: Eli Lilly and Company, Indianapolis, Indiana, United States of America

Affiliation Oncology Center and Medical Clinic III, Asklepios Clinic St. George, Hamburg, Germany
⨯
Augusto D. Luchessi,

Current address: Laboratory of Biotechnology, School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil

Affiliation Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
Tavane D. Cambiaghi,

Current address: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil

Affiliation Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
Mainul Hoque,

Affiliation Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
Michael Spino,

Affiliations Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, ApoPharma Inc., Toronto, Ontario, Canada
⨯
Darlene D'Alliessi Gandolfi,

Affiliation Department of Chemistry, Manhattanville College, Purchase, New York, United States of America
⨯
Debra S. Heller,

Affiliation Department of Pathology & Laboratory Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
Sukhwinder Singh,

Affiliation Department of Pathology & Laboratory Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
Myung Hee Park,

Affiliation Oral and Pharyngeal Cancer Branch, National Institute for Dental and Craniofacial Research, Bethesda, Maryland, United States of America
⨯
Bernadette M. Cracchiolo,

Affiliation Department of Obstetrics, Gynecology & Women’s Health, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
Fernando Tricta,

Affiliation ApoPharma Inc., Toronto, Ontario, Canada
⨯
John Connelly,

Affiliation ApoPharma Inc., Toronto, Ontario, Canada
⨯
Anthony M. Popowicz,

Affiliation Department of Information Technology, Rockefeller University, New York, New York, United States of America
⨯
Richard A. Cone,

Affiliation Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Bart Holland,

Affiliation Department of Preventive Medicine & Community Health, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
Tsafi Pe’ery,

Affiliations Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
[ ... ],
Michael B. Mathews

* E-mail: hanaushm@njms.rutgers.edu (HMH); mathews@njms.rutgers.edu (MBM)

Affiliation Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America
⨯
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Drug-Induced Reactivation of Apoptosis Abrogates HIV-1 Infection

Hartmut M. Hanauske-Abel,
Deepti Saxena,
Paul E. Palumbo,
Axel-Rainer Hanauske,
Augusto D. Luchessi,
Tavane D. Cambiaghi,
Mainul Hoque,
Michael Spino,
Darlene D'Alliessi Gandolfi,
Debra S. Heller

Published: September 23, 2013
https://doi.org/10.1371/journal.pone.0074414

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Media coverage of this article

Posted by PLOS_ONE_Group on 30 Sep 2013 at 18:02 GMT

The following articles represent some of the media coverage that has occurred for this paper:

Publication: CBS News
Title: “Can a foot cream really do battle with HIV?”
http://www.cbsnews.com/83...

Publication: Health 24
Title: “Nail fungus drug may help against HIV”
http://www.health24.com/M...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

Media coverage of this article

PLOS_ONE_Group replied to PLOS_ONE_Group on 04 Oct 2013 at 21:45 GMT

The following articles represent some of the media coverage that has occurred for this paper:

Publication: Rutgers News
Title: “Drug Is Found to Eradicate HIV Permanently from Infected Cells | Media Relations”
http://news.rutgers.edu/n...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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Drug-Induced Reactivation of Apoptosis Abrogates HIV-1 Infection

Drug-Induced Reactivation of Apoptosis Abrogates HIV-1 Infection

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Media coverage of this article

Posted by PLOS_ONE_Group on 30 Sep 2013 at 18:02 GMT

Media coverage of this article

PLOS_ONE_Group replied to PLOS_ONE_Group on 04 Oct 2013 at 21:45 GMT