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Research Article

Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

  • Hongjie Zhu equal contributor,

    equal contributor Contributed equally to this work with: Hongjie Zhu, Mikhail B. Bogdanov

    Affiliation: Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

    X
  • Mikhail B. Bogdanov equal contributor,

    equal contributor Contributed equally to this work with: Hongjie Zhu, Mikhail B. Bogdanov

    Affiliation: Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York, United States of America

    X
  • Stephen H. Boyle,

    Affiliation: Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

    X
  • Wayne Matson,

    Affiliation: Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America

    X
  • Swati Sharma,

    Affiliation: Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America

    X
  • Samantha Matson,

    Affiliations: Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Erik Churchill,

    Affiliation: Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

    X
  • Oliver Fiehn,

    Affiliation: Genome Center, University of California Davis, Davis, California, United States of America

    X
  • John A. Rush,

    Affiliation: Duke-NUS Graduate Medical School, Singapore, Singapore

    X
  • Ranga R. Krishnan,

    Affiliations: Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America, Duke-NUS Graduate Medical School, Singapore, Singapore

    X
  • Eve Pickering,

    Affiliation: Pfizer Global R&D, Clinical Research Statistics, Groton, Connecticut, United States of America

    X
  • Marielle Delnomdedieu,

    Affiliation: Pfizer Global R&D, Neuroscience Clinical Research, Groton, Connecticut, United States of America

    X
  • Rima Kaddurah-Daouk mail,

    rima.kaddurahdaouk.duke.edu

    Affiliation: Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America

    X
  • Pharmacometabolomics Research Network
  • Published: July 17, 2013
  • DOI: 10.1371/journal.pone.0068283

Reader Comments (3)

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Great study. Any possiblity of a similar study on...

Posted by JacNova on 27 Jul 2013 at 17:58 GMT

The effects of Dextroamphetamine on dopamine and norepinephrine?

This would be extremely useful for the many individuals that have certain types of depression as well as other psychiatric syndromes.

No competing interests declared.