Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

Hongjie Zhu; Mikhail B. Bogdanov; Stephen H. Boyle; Wayne Matson; Swati Sharma; Samantha Matson; Erik Churchill; Oliver Fiehn; John A. Rush; Ranga R. Krishnan; Eve Pickering; Marielle Delnomdedieu; Rima Kaddurah-Daouk; Pharmacometabolomics Research Network

doi:10.1371/journal.pone.0068283

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Peer-reviewed

Research Article

Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

Hongjie Zhu ,

Contributed equally to this work with: Hongjie Zhu, Mikhail B. Bogdanov

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America
⨯
Mikhail B. Bogdanov ,

Contributed equally to this work with: Hongjie Zhu, Mikhail B. Bogdanov

Affiliation Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York, United States of America
⨯
Stephen H. Boyle,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America
⨯
Wayne Matson,

Affiliation Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America
⨯
Swati Sharma,

Affiliation Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America
⨯
Samantha Matson,

Affiliations Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Erik Churchill,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America
⨯
Oliver Fiehn,

Affiliation Genome Center, University of California Davis, Davis, California, United States of America
⨯
John A. Rush,

Affiliation Duke-NUS Graduate Medical School, Singapore, Singapore
⨯
Ranga R. Krishnan,

Affiliations Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America, Duke-NUS Graduate Medical School, Singapore, Singapore
⨯
Eve Pickering,

Affiliation Pfizer Global R&D, Clinical Research Statistics, Groton, Connecticut, United States of America
⨯
Marielle Delnomdedieu,

Affiliation Pfizer Global R&D, Neuroscience Clinical Research, Groton, Connecticut, United States of America
⨯
Rima Kaddurah-Daouk ,

* E-mail: rima.kaddurahdaouk.duke.edu

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America
⨯
Pharmacometabolomics Research Network

Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

Hongjie Zhu,
Mikhail B. Bogdanov,
Stephen H. Boyle,
Wayne Matson,
Swati Sharma,
Samantha Matson,
Erik Churchill,
Oliver Fiehn,
John A. Rush,
Ranga R. Krishnan

Published: July 17, 2013
https://doi.org/10.1371/journal.pone.0068283

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No competing interests declared.

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Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

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addl media coverage

Posted by JacNova on 27 Jul 2013 at 17:36 GMT