Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

Hongjie Zhu; Mikhail B. Bogdanov; Stephen H. Boyle; Wayne Matson; Swati Sharma; Samantha Matson; Erik Churchill; Oliver Fiehn; John A. Rush; Ranga R. Krishnan; Eve Pickering; Marielle Delnomdedieu; Rima Kaddurah-Daouk; Pharmacometabolomics Research Network

doi:10.1371/journal.pone.0068283

Loading metrics

Open Access

Peer-reviewed

Research Article

Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

Hongjie Zhu ,

Contributed equally to this work with: Hongjie Zhu, Mikhail B. Bogdanov

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America
⨯
Mikhail B. Bogdanov ,

Contributed equally to this work with: Hongjie Zhu, Mikhail B. Bogdanov

Affiliation Department of Neurology and Neuroscience Weill Cornell Medical College, New York, New York, United States of America
⨯
Stephen H. Boyle,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America
⨯
Wayne Matson,

Affiliation Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America
⨯
Swati Sharma,

Affiliation Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America
⨯
Samantha Matson,

Affiliations Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, Massachusetts, United States of America, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Erik Churchill,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America
⨯
Oliver Fiehn,

Affiliation Genome Center, University of California Davis, Davis, California, United States of America
⨯
John A. Rush,

Affiliation Duke-NUS Graduate Medical School, Singapore, Singapore
⨯
Ranga R. Krishnan,

Affiliations Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America, Duke-NUS Graduate Medical School, Singapore, Singapore
⨯
Eve Pickering,

Affiliation Pfizer Global R&D, Clinical Research Statistics, Groton, Connecticut, United States of America
⨯
Marielle Delnomdedieu,

Affiliation Pfizer Global R&D, Neuroscience Clinical Research, Groton, Connecticut, United States of America
⨯
Rima Kaddurah-Daouk ,

* E-mail: rima.kaddurahdaouk.duke.edu

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, United States of America
⨯
Pharmacometabolomics Research Network

Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

Hongjie Zhu,
Mikhail B. Bogdanov,
Stephen H. Boyle,
Wayne Matson,
Swati Sharma,
Samantha Matson,
Erik Churchill,
Oliver Fiehn,
John A. Rush,
Ranga R. Krishnan

Published: July 17, 2013
https://doi.org/10.1371/journal.pone.0068283

Reader Comments

Post a new comment on this article

Media Coverage of this Article

Posted by PLOS_ONE_Group on 22 Jul 2013 at 22:24 GMT

The following articles represent some of the media coverage that has occurred for this paper:

Publication: EurekAlert press release
Title: “Biochemical mapping helps explain who will respond to antidepressants”
http://www.eurekalert.org...

Publication: News Medical
Title: “Metabolomics tools predict who can benefit from treatment with certain antidepressants”
http://www.news-medical.n...

Publication: Psych Central
Title: “Biochemical Mapping Helps Match Antidepressant to Individual | Psych Central News”
http://psychcentral.com/n...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article

Competing interests declared: PLOS ONE Staff

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Tryptophan
Is the Subject Area "Tryptophan" applicable to this article?

Thanks for your feedback.
Metabolic pathways
Is the Subject Area "Metabolic pathways" applicable to this article?

Thanks for your feedback.
Metabolites
Is the Subject Area "Metabolites" applicable to this article?

Thanks for your feedback.
Serotonin
Is the Subject Area "Serotonin" applicable to this article?

Thanks for your feedback.
Tyrosine
Is the Subject Area "Tyrosine" applicable to this article?

Thanks for your feedback.
Depression
Is the Subject Area "Depression" applicable to this article?

Thanks for your feedback.
Amino acid metabolism
Is the Subject Area "Amino acid metabolism" applicable to this article?

Thanks for your feedback.
Purines
Is the Subject Area "Purines" applicable to this article?

Thanks for your feedback.

Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Media Coverage of this Article

Posted by PLOS_ONE_Group on 22 Jul 2013 at 22:24 GMT