Research Article

The p53 Tumor Suppressor-Like Protein nvp63 Mediates Selective Germ Cell Death in the Sea Anemone Nematostella vectensis

  • Sandra Pankow,

    Affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

  • Casimir Bamberger mail

    To whom correspondence should be addressed. E-mail:

    Affiliation: Sundgauallee 64, Freiburg, Germany

  • Published: September 12, 2007
  • DOI: 10.1371/journal.pone.0000782

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Referee Comments: Referee 1 (Rob Steele)

Posted by PLoS_ONE_Group on 27 Sep 2007 at 22:51 GMT

Reviewer 1's Review (Rob Steele)

This manuscript presents the first study on p53 homologues in a non-bilaterian animal. As such it makes an important contribution to our understanding of the evolution of a gene which has been the major focus of work in a large number of laboratories. This paper provides the first proof that p53 genes are present in diploblastic animals and it also provides evidence of at least one function for the gene, protection of the germ line from genotoxic damage.

N.B. These are the general comments made by the reviewer when reviewing this paper in light of which the manuscript was revised. Specific points addressed during revision of the paper are not shown.