Matrix Metalloproteinase-10 Is Required for Lung Cancer Stem Cell Maintenance, Tumor Initiation and Metastatic Potential

Verline Justilien; Roderick P. Regala; I-Chu Tseng; Michael P. Walsh; Jyotica Batra; Evette S. Radisky; Nicole R. Murray; Alan P. Fields

doi:10.1371/journal.pone.0035040

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Open Access

Peer-reviewed

Research Article

Matrix Metalloproteinase-10 Is Required for Lung Cancer Stem Cell Maintenance, Tumor Initiation and Metastatic Potential

Verline Justilien ,

Contributed equally to this work with: Verline Justilien, Roderick P. Regala

Affiliation Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
⨯
Roderick P. Regala ,

Contributed equally to this work with: Verline Justilien, Roderick P. Regala

Affiliation Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
⨯
I-Chu Tseng,

Affiliation Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
⨯
Michael P. Walsh,

Affiliation Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
⨯
Jyotica Batra,

Affiliation Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
⨯
Evette S. Radisky,

Affiliation Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
⨯
Nicole R. Murray,

Affiliation Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
⨯
Alan P. Fields

* E-mail: fields.alan@mayo.edu

Affiliation Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
⨯

Matrix Metalloproteinase-10 Is Required for Lung Cancer Stem Cell Maintenance, Tumor Initiation and Metastatic Potential

Verline Justilien,
Roderick P. Regala,
I-Chu Tseng,
Michael P. Walsh,
Jyotica Batra,
Evette S. Radisky,
Nicole R. Murray,
Alan P. Fields

Published: April 24, 2012
https://doi.org/10.1371/journal.pone.0035040

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 27 Apr 2012 at 21:43 GMT

The following articles represent some of the media coverage that has occurred for this paper:

Publication: GEN Genetic Engineering and Biotechnology News
Title: “GEN | News Highlights: Researchers Find Gene Key to Maintaining Lung Cancer Stem Cells, Promoting Tumor Initiation, and Metastases”
http://www.genengnews.com...

Publication: Mayo Clinic
Title: “Mayo Clinic - Mayo Clinic Identifies Gene Critical to Development and Spread of Lung Cancer”
http://www.mayoclinic.org...

Publication: Cancer Research UK
Title: “Molecule linked to lung cancer growth and spread : Cancer Research UK”
http://info.cancerresearc...

Publication: Fox News
Title: “Scientists identify 'critical' gene for development and spread of lung cancer | Fox News”
http://www.foxnews.com/he...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

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Non-small cell lung cancer
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Matrix Metalloproteinase-10 Is Required for Lung Cancer Stem Cell Maintenance, Tumor Initiation and Metastatic Potential

Matrix Metalloproteinase-10 Is Required for Lung Cancer Stem Cell Maintenance, Tumor Initiation and Metastatic Potential

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 27 Apr 2012 at 21:43 GMT