Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

Gene-Jack Wang; Nora D. Volkow; Timothy Wigal; Scott H. Kollins; Jeffrey H. Newcorn; Frank Telang; Jean Logan; Millard Jayne; Christopher T. Wong; Hao Han; Joanna S. Fowler; Wei Zhu; James M. Swanson

doi:10.1371/journal.pone.0063023

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Research Article

Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

Gene-Jack Wang ,

* E-mail: gjwang@bnl.gov

Affiliations Department of Radiology, Stony Brook University, Stony Brook, New York, United States of America, Bioscience Department, Brookhaven National Laboratory, Upton, New York, United States of America, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Nora D. Volkow,

Affiliations National Institute on Drug Abuse, Bethesda, Maryland, United States of America, Neuroimaging Lab, National Institute on Alcohol Abuse and Alcoholism Intramural Research Program, Upton, New York, United States of America
⨯
Timothy Wigal,

Affiliation Department of Pediatrics, University of California Irvine, Irvine, California, United States of America
⨯
Scott H. Kollins,

Affiliation Department of Psychiatry, Duke University, Durham, North Carolina, United States of America
⨯
Jeffrey H. Newcorn,

Affiliation Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Frank Telang,

Affiliation Neuroimaging Lab, National Institute on Alcohol Abuse and Alcoholism Intramural Research Program, Upton, New York, United States of America
⨯
Jean Logan,

Affiliation Bioscience Department, Brookhaven National Laboratory, Upton, New York, United States of America
⨯
Millard Jayne,

Affiliation Neuroimaging Lab, National Institute on Alcohol Abuse and Alcoholism Intramural Research Program, Upton, New York, United States of America
⨯
Christopher T. Wong,

Affiliation Neuroimaging Lab, National Institute on Alcohol Abuse and Alcoholism Intramural Research Program, Upton, New York, United States of America
⨯
Hao Han,

Affiliation Department of Mathematics and Applied Sciences, Stony Brook University, Stony Brook, New York, United States of America
⨯
Joanna S. Fowler,

Affiliations Bioscience Department, Brookhaven National Laboratory, Upton, New York, United States of America, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Wei Zhu,

Affiliation Department of Mathematics and Applied Sciences, Stony Brook University, Stony Brook, New York, United States of America
⨯
James M. Swanson

Affiliation Department of Pediatrics, University of California Irvine, Irvine, California, United States of America
⨯

Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

Gene-Jack Wang,
Nora D. Volkow,
Timothy Wigal,
Scott H. Kollins,
Jeffrey H. Newcorn,
Frank Telang,
Jean Logan,
Millard Jayne,
Christopher T. Wong,
Hao Han

Published: May 15, 2013
https://doi.org/10.1371/journal.pone.0063023

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 17 May 2013 at 22:59 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Press Release
Title: “Long-term ADHD treatment increases brain dopamine transporter levels, may affect drug efficacy”
http://www.eurekalert.org...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 17 May 2013 at 22:59 GMT