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Research Article

Anti-calmodulins and Tricyclic Adjuvants in Pain Therapy Block the TRPV1 Channel

  • Zoltán Oláh mail,

    To whom correspondence should be addressed. E-mail: zolah@brc.hu

    Affiliations: Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary, Acheuron Hungary Ltd., Szeged, Hungary, Acheuron Pharmaceuticals Inc., San Diego, California, United States of America

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  • Katalin Jósvay,

    Affiliation: Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

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  • László Pecze,

    Affiliation: Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

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  • Tamás Letoha,

    Affiliations: Department of Medical Chemistry, Faculty of General Medicine, University of Szeged, Szeged, Hungary, Acheuron Hungary Ltd., Szeged, Hungary

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  • Norbert Babai,

    Affiliation: Department of Experimental Zoology and Neurobiology, University of Pécs, Pécs, Hungary

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  • Dénes Budai,

    Affiliation: Department of Biology, Gyula Juh‡sz Faculty of Education, University of Szeged, Szeged, Hungary

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  • Ferenc Ötvös,

    Affiliation: Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

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  • Sándor Szalma,

    Affiliation: Acheuron Pharmaceuticals Inc., San Diego, California, United States of America

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  • Csaba Vizler

    Affiliation: Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

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  • Published: June 20, 2007
  • DOI: 10.1371/journal.pone.0000545

Reader Comments (2)

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pas tres

Posted by FAROUCHE_OMBRÉ on 17 Jul 2007 at 05:06 GMT

TRP cation channel
http://plosone.org/article/info:doi/10.1371/journal.pone.0000545#article1.body1.sec1.p1

Acetylglucosaminyltransferase of the TRP (transient receptor potential) super family
synthesis from Tryptophan An important part of many pharmaceuticals, and many compounds of industrial and technological importance as ImLA do release Ca2+ though the TRP citation has remained largely unknown “information is scarce” as prg1 such as…These observations suggest still debated and small conductance K+ and the formation and Ca2+ spiking KIAA0434-MSN analysis which was carried out to profile which was carried out to profile of the TRP. 7/16/2007