Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas

Jenny M. Kreahling; Parastou Foroutan; Damon Reed; Gary Martinez; Tiffany Razabdouski; Marilyn M. Bui; Meera Raghavan; Douglas Letson; Robert J. Gillies; Soner Altiok

doi:10.1371/journal.pone.0057523

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Peer-reviewed

Research Article

Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas

Jenny M. Kreahling,

Affiliation Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Parastou Foroutan,

Affiliation Department of Cancer Imaging Research, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Damon Reed,

Affiliations Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America, Sarcoma Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Gary Martinez,

Affiliation Department of Cancer Imaging Research, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Tiffany Razabdouski,

Affiliation Department of Comparative Medicine, University of South Florida, Tampa, Florida, United States of America
⨯
Marilyn M. Bui,

Affiliations Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America, Sarcoma Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Meera Raghavan,

Affiliation Department of Diagnostic Imaging and Sarcoma, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Douglas Letson,

Affiliation Sarcoma Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Robert J. Gillies,

Affiliation Department of Cancer Imaging Research, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Soner Altiok

* E-mail: soner.altiok@moffitt.org

Affiliations Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America, Sarcoma Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯

Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas

Jenny M. Kreahling,
Parastou Foroutan,
Damon Reed,
Gary Martinez,
Tiffany Razabdouski,
Marilyn M. Bui,
Meera Raghavan,
Douglas Letson,
Robert J. Gillies,
Soner Altiok

Published: March 8, 2013
https://doi.org/10.1371/journal.pone.0057523

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 22 Apr 2013 at 16:16 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Emax Health
Title: “Experimental Drug Added to Chemotherapy May Significantly Reduce Sarcoma Tumors”
http://www.emaxhealth.com...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 03 May 2013 at 20:42 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Oncology Nurse Advisor
Title: “Sarcoma drug duo more effective than one or the other - ONA”
http://www.oncologynursea...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas

Wee1 Inhibition by MK-1775 Leads to Tumor Inhibition and Enhances Efficacy of Gemcitabine in Human Sarcomas

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 22 Apr 2013 at 16:16 GMT

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 03 May 2013 at 20:42 GMT