Research Article

A Model of Functional Brain Connectivity and Background Noise as a Biomarker for Cognitive Phenotypes: Application to Autism

  • Luis García Domínguez,

    Affiliation: Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada

  • José Luis Pérez Velázquez,

    Affiliation: Neuroscience and Mental Health Programme, Brain and Behaviour Centre, Division of Neurology, Hospital for Sick Children; Institute of Medical Science and Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada

  • Roberto Fernández Galán mail

    Affiliation: Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

  • Published: April 17, 2013
  • DOI: 10.1371/journal.pone.0061493

Reader Comments (2)

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A Possible New Explanation of Increased Connectivity in Autism

Posted by jamesmhoward on 20 Apr 2013 at 11:24 GMT

The increased connectivity reported by García Domínquez, et al., may be explained by effects of testosterone and dehydroepiandrosterone (DHEA) in utero. "A Possible Explanation of Autism based on Elevated Maternal Testosterone: A Mechanism that may Explain Differential Growth and Development" at:

No competing interests declared.