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Research Article

A Model of Functional Brain Connectivity and Background Noise as a Biomarker for Cognitive Phenotypes: Application to Autism

  • Luis García Domínguez,

    Affiliation: Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada

  • José Luis Pérez Velázquez,

    Affiliation: Neuroscience and Mental Health Programme, Brain and Behaviour Centre, Division of Neurology, Hospital for Sick Children; Institute of Medical Science and Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada

  • Roberto Fernández Galán mail


    Affiliation: Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

  • Published: April 17, 2013
  • DOI: 10.1371/journal.pone.0061493

Reader Comments (2)

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Is this application specific to Autism?

Posted by BCSt on 18 Apr 2013 at 14:32 GMT

There is nothing in the article that indicates these findings are specific to Autism.
The next step should be an identical study on subjects diagnosed with Fetal Alcohol Spectrum Disorder [ Fetal Alcohol Syndrome, Alcohol Related Neurodevelopment Disorder ]

Barry Stanley, MB,Ch.B. F.R.C.S.[C]

No competing interests declared.

RE: Is this application specific to Autism?

rfgalan replied to BCSt on 18 Apr 2013 at 18:36 GMT

The analytic method is general and can be applied to investigate other phenotypes, as indicated in the title. However, in this study we only analyzed data from autistic children compared to non-autistic children.

No competing interests declared.