Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid Progenitors

Tea Soon Park; Jeffrey S. Huo; Ann Peters; C. Conover Talbot Jr.; Karan Verma; Ludovic Zimmerlin; Ian M. Kaplan; Elias T. Zambidis

doi:10.1371/journal.pone.0042838

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Research Article

Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid Progenitors

Tea Soon Park,

Affiliations Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯
Jeffrey S. Huo,

Affiliations Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯
Ann Peters,

Affiliations Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯
C. Conover Talbot Jr.,

Affiliation Institute for Basic Biomedical Sciences at Johns Hopkins, Baltimore, Maryland, United States of America
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Karan Verma,

Affiliations Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯
Ludovic Zimmerlin,

Affiliations Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯
Ian M. Kaplan,

Affiliations Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯
Elias T. Zambidis

* E-mail: ezambid1@jhmi.edu

Affiliations Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯

Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid Progenitors

Tea Soon Park,
Jeffrey S. Huo,
Ann Peters,
C. Conover Talbot Jr.,
Karan Verma,
Ludovic Zimmerlin,
Ian M. Kaplan,
Elias T. Zambidis

Published: August 8, 2012
https://doi.org/10.1371/journal.pone.0042838

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Citation

Posted by sheldonz on 13 Apr 2013 at 00:26 GMT

Purified (>95%) human CD34+ progenitors from neonatal CB, adult bone marrow (BM), and 20–22 week-old fetal liver (FL) were obtained from pooled donors, and purchased from ALLCELLS http://www.allcells.com (Emeryville, CA)

No competing interests declared.

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Fibroblasts
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Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid Progenitors

Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid Progenitors

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Citation

Posted by sheldonz on 13 Apr 2013 at 00:26 GMT