Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

Grietje Krabbe; Annett Halle; Vitali Matyash; Jan L. Rinnenthal; Gina D. Eom; Ulrike Bernhardt; Kelly R. Miller; Stefan Prokop; Helmut Kettenmann; Frank L. Heppner

doi:10.1371/journal.pone.0060921

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Research Article

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

Grietje Krabbe ,

Contributed equally to this work with: Grietje Krabbe, Annett Halle, Helmut Kettenmann, Frank L. Heppner

Current address: Gladstone Institute of Neurological Disease, San Francisco, California, United States of America

Affiliation Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany
⨯
Annett Halle ,

Contributed equally to this work with: Grietje Krabbe, Annett Halle, Helmut Kettenmann, Frank L. Heppner

Affiliations Department of Neuropathology, Charité-Universitätsmedizin Berlin, Berlin, Germany, Center of Advanced European Studies and Research (caesar), Bonn, Germany
⨯
Vitali Matyash,

Affiliation Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany
⨯
Jan L. Rinnenthal,

Affiliation Department of Neuropathology, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Gina D. Eom,

Affiliation Department of Neuropathology, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Ulrike Bernhardt,

Affiliation Department of Neuropathology, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Kelly R. Miller,

Affiliation Department of Neuropathology, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Stefan Prokop,

Affiliation Department of Neuropathology, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯
Helmut Kettenmann ,

Contributed equally to this work with: Grietje Krabbe, Annett Halle, Helmut Kettenmann, Frank L. Heppner

* E-mail: kettenmann@mdc-berlin.de (HK); frank.heppner@charite.de (FLH)

Affiliation Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany
⨯
Frank L. Heppner

Contributed equally to this work with: Grietje Krabbe, Annett Halle, Helmut Kettenmann, Frank L. Heppner

* E-mail: kettenmann@mdc-berlin.de (HK); frank.heppner@charite.de (FLH)

Affiliation Department of Neuropathology, Charité-Universitätsmedizin Berlin, Berlin, Germany
⨯

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

Grietje Krabbe,
Annett Halle,
Vitali Matyash,
Jan L. Rinnenthal,
Gina D. Eom,
Ulrike Bernhardt,
Kelly R. Miller,
Stefan Prokop,
Helmut Kettenmann,
Frank L. Heppner

Published: April 8, 2013
https://doi.org/10.1371/journal.pone.0060921

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 12 Apr 2013 at 21:09 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Eureka Alert
Title: “New findings on the brain's immune cells during Alzheimer's disease progression”
http://www.eurekalert.org...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 22 Apr 2013 at 16:29 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: News Medical
Title: “Study sheds light on role of microglia during progression of Alzheimer's disease”
http://www.news-medical.n...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 12 Apr 2013 at 21:09 GMT

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 22 Apr 2013 at 16:29 GMT