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Research Article

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

  • Sebastiano Collino mail,

    sebastiano.collino@rd.nestle.com

    Affiliation: Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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  • Ivan Montoliu,

    Affiliation: Applied Mathematics, NESTEC SA, Nestlé Research Center, Lausanne, Switzerland

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  • François-Pierre J. Martin,

    Affiliation: Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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  • Max Scherer,

    Affiliation: Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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  • Daniela Mari,

    Affiliations: Department of Medical Sciences, University of Milan, Milan, Italy, Geriatric Unit Ca' Grande Foundation Maggiore Policlinico Hospital, Milan, Italy

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  • Stefano Salvioli,

    Affiliations: Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Laura Bucci,

    Affiliations: Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Rita Ostan,

    Affiliations: Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Daniela Monti,

    Affiliation: Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy

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  • Elena Biagi,

    Affiliation: Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

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  • Patrizia Brigidi,

    Affiliation: Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy

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  • Claudio Franceschi,

    Affiliations: Department of Experimental Pathology, University of Bologna, Bologna, Italy, Interdepartmental Centre L. Galvani, University of Bologna, Bologna, Italy

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  • Serge Rezzi

    Affiliation: Proteomics and Metabonomics, Nestlé Institute of Health Sciences SA, Campus EPFL, Quartier de l'innovation, Lausanne, Switzerland

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  • Published: March 06, 2013
  • DOI: 10.1371/journal.pone.0056564

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Media Coverage of This Article

Posted by PLoS_ONE_Group on 15 Mar 2013 at 18:32 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Real Clear Science
Title: “The Metabolic Signature of Really Old People”
http://www.realclearscien...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS One Staff

Media Coverage of This Article

PLoS_ONE_Group replied to PLoS_ONE_Group on 24 Sep 2013 at 16:13 GMT

The following articles represent some of the media coverage that has occurred for this paper:

Publication: MarketWatch
Title: “Nestle research identifies metabolic signature for long life - MarketWatch”
http://www.marketwatch.co...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff