Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs

Melissa C. Paoloni; Christina Mazcko; Elizabeth Fox; Timothy Fan; Susan Lana; William Kisseberth; David M. Vail; Kaylee Nuckolls; Tanasa Osborne; Samuel Yalkowsy; Daniel Gustafson; Yunkai Yu; Liang Cao; Chand Khanna

doi:10.1371/journal.pone.0011013

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Open Access

Peer-reviewed

Research Article

Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs

Melissa C. Paoloni,

Affiliation Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Christina Mazcko,

Affiliation Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Elizabeth Fox,

Affiliation Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Timothy Fan,

Affiliation University of Illinois, Urbana, Illinois, United States of America
⨯
Susan Lana,

Affiliation Colorado State University, Fort Collins, Colorado, United States of America
⨯
William Kisseberth,

Affiliation Ohio State University, Columbus, Ohio, United States of America
⨯
David M. Vail,

Affiliation University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Kaylee Nuckolls,

Affiliation Tumor Metastasis and Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Tanasa Osborne,

Affiliation Tumor Metastasis and Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Samuel Yalkowsy,

Affiliation University of Arizona College of Pharmacy, Tucson, Arizona, United States of America
⨯
Daniel Gustafson,

Affiliation Colorado State University, Fort Collins, Colorado, United States of America
⨯
Yunkai Yu,

Affiliation Molecular Targets Core, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Liang Cao,

Affiliation Molecular Targets Core, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Chand Khanna

* E-mail: khannac@mail.nih.gov

Affiliations Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America, Tumor Metastasis and Biology Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯

Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs

Melissa C. Paoloni,
Christina Mazcko,
Elizabeth Fox,
Timothy Fan,
Susan Lana,
William Kisseberth,
David M. Vail,
Kaylee Nuckolls,
Tanasa Osborne,
Samuel Yalkowsy

Published: June 8, 2010
https://doi.org/10.1371/journal.pone.0011013

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Competing interests declared: PLOS ONE Staff

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Dogs
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Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs

Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 02 Mar 2013 at 00:28 GMT