Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

Katerina V. Savelieva; Shulei Zhao; Vladimir M. Pogorelov; Indrani Rajan; Qi Yang; Emily Cullinan; Thomas H. Lanthorn

doi:10.1371/journal.pone.0003301

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Peer-reviewed

Research Article

Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

Katerina V. Savelieva ,

* E-mail: *ksavelieva@lexpharma.com

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America
⨯
Shulei Zhao ,

Contributed equally to this work with: Shulei Zhao, Vladimir M. Pogorelov

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America
⨯
Vladimir M. Pogorelov ,

Contributed equally to this work with: Shulei Zhao, Vladimir M. Pogorelov

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America
⨯
Indrani Rajan,

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America
⨯
Qi Yang,

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America
⨯
Emily Cullinan,

Current address: Baylor College of Medicine, Houston, Texas, United States of America

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America
⨯
Thomas H. Lanthorn

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America
⨯

Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

Katerina V. Savelieva,
Shulei Zhao,
Vladimir M. Pogorelov,
Indrani Rajan,
Qi Yang,
Emily Cullinan,
Thomas H. Lanthorn

Published: October 15, 2008
https://doi.org/10.1371/journal.pone.0003301

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Publisher's Note: Change to corresponding author e-mail address

Posted by SBDR on 08 Jul 2010 at 20:58 GMT

The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and central nervous systems.
http://plosone.org/article/info:doi/10.1371/journal.pone.0003301#article1.front1.article-meta1.abstract1.p1

Corresponding author Katerina Savelieva's e-mail address and affiliation have changed.
She may be reached at k_savelieva@yahoo.com
Her new affiliation is PsychoGenics Incorporated, Tarrytown, New York, United States of America.

No competing interests declared.

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Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

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Publisher's Note: Change to corresponding author e-mail address

Posted by SBDR on 08 Jul 2010 at 20:58 GMT