What Does It Take to Synergistically Combine Sub-Potent Natural Products into Drug-Level Potent Combinations?

• Chu Qin,

  Affiliations Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China, Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, Singapore,Singapore, NUS Graduate School for Integrative Sciences and Engineering, Singapore, Singapore

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• Kai Leng Tan,

  Affiliation Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, Singapore,Singapore

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• Cun Long Zhang,

  Affiliations Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China

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• Chun Yan Tan,

  Affiliations Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China

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• Yu Zong Chen ,

  * E-mail: phacyz@nus.edu.sg (YZC); Jiangyy@sz.tsinghua.edu.cn (YYJ)

  Affiliations Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China, Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, Singapore,Singapore

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• Yu Yang Jiang

  * E-mail: phacyz@nus.edu.sg (YZC); Jiangyy@sz.tsinghua.edu.cn (YYJ)

  Affiliations Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China

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