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Does FTY inhibit directly Bcr-Abl ?

Posted by jukkaW on 28 Jan 2013 at 11:27 GMT

It is surely interesting to see data that FTY720 effects on cancer cell survival might not be mediated by PP2A activation. I have heard from that FTY720 might directly inhibit Abl kinase activity, this could be an explanation for selective function in Ph(+) cells and it would be very interesting to see whether this mechanism would explain the disease specificity. Is it know whether this possible cause of misinterpretation of FTY720 effects has been excluded in any of the previous studies. If not, this would be worth studying.

No competing interests declared.