Exendin-4 Ameliorates Motor Neuron Degeneration in Cellular and Animal Models of Amyotrophic Lateral Sclerosis

Yazhou Li; Srinivasulu Chigurupati; Harold W. Holloway; Mohamed Mughal; David Tweedie; Daniel A. Bruestle; Mark P. Mattson; Yun Wang; Brandon K. Harvey; Balmiki Ray; Debomoy K. Lahiri; Nigel H. Greig

doi:10.1371/journal.pone.0032008

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Peer-reviewed

Research Article

Exendin-4 Ameliorates Motor Neuron Degeneration in Cellular and Animal Models of Amyotrophic Lateral Sclerosis

Yazhou Li,

Affiliation Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Srinivasulu Chigurupati,

Affiliation Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Harold W. Holloway,

Affiliation Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Mohamed Mughal,

Affiliation Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
David Tweedie,

Affiliation Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Daniel A. Bruestle,

Affiliation Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Mark P. Mattson,

Affiliation Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Yun Wang,

Affiliation Molecular Neuropsychiatry Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Brandon K. Harvey,

Affiliation Molecular Neuropsychiatry Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Balmiki Ray,

Affiliation Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Debomoy K. Lahiri,

Affiliation Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Nigel H. Greig

* E-mail: Greign@grc.nia.nih.gov

Affiliation Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯

Exendin-4 Ameliorates Motor Neuron Degeneration in Cellular and Animal Models of Amyotrophic Lateral Sclerosis

Yazhou Li,
Srinivasulu Chigurupati,
Harold W. Holloway,
Mohamed Mughal,
David Tweedie,
Daniel A. Bruestle,
Mark P. Mattson,
Yun Wang,
Brandon K. Harvey,
Balmiki Ray

Published: February 23, 2012
https://doi.org/10.1371/journal.pone.0032008

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Insulin sensititvity

Posted by jedsrose on 02 Mar 2012 at 13:07 GMT

The brain is a highly insulin sensitive organ (phrase in the text)....This phrase requires further consideration. For glucose entry, only very specific areas may be considered as such. For the whole brain it does not have support.

No competing interests declared.

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Exendin-4 Ameliorates Motor Neuron Degeneration in Cellular and Animal Models of Amyotrophic Lateral Sclerosis

Exendin-4 Ameliorates Motor Neuron Degeneration in Cellular and Animal Models of Amyotrophic Lateral Sclerosis

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Insulin sensititvity

Posted by jedsrose on 02 Mar 2012 at 13:07 GMT