Matrix Metalloproteinase 14 in the Zebrafish: An Eye on Retinal and Retinotectal Development

Els Janssens; Djoere Gaublomme; Lies De Groef; Veerle M. Darras; Lut Arckens; Nathalie Delorme; Filip Claes; Inge Van Hove; Lieve Moons

doi:10.1371/journal.pone.0052915

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Research Article

Matrix Metalloproteinase 14 in the Zebrafish: An Eye on Retinal and Retinotectal Development

Els Janssens,

Affiliation Research Group Neural Circuit Development and Regeneration, Department of Biology, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium
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Djoere Gaublomme,

Affiliation Research Group Neural Circuit Development and Regeneration, Department of Biology, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium
⨯
Lies De Groef,

Affiliation Research Group Neural Circuit Development and Regeneration, Department of Biology, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium
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Veerle M. Darras,

Affiliation Laboratory of Comparative Endocrinology, Department of Biology, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium
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Lut Arckens,

Affiliation Laboratory of Neuroplasticity and Neuroproteomics, Department of Biology, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium
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Nathalie Delorme,

Affiliation Research Group Neural Circuit Development and Regeneration, Department of Biology, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium
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Filip Claes,

Affiliation Research Group Neural Circuit Development and Regeneration, Department of Biology, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium
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Inge Van Hove,

Affiliation Research Group Neural Circuit Development and Regeneration, Department of Biology, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium
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Lieve Moons

* E-mail: lieve.moons@bio.kuleuven.be

Affiliation Research Group Neural Circuit Development and Regeneration, Department of Biology, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium
⨯

Matrix Metalloproteinase 14 in the Zebrafish: An Eye on Retinal and Retinotectal Development

Els Janssens,
Djoere Gaublomme,
Lies De Groef,
Veerle M. Darras,
Lut Arckens,
Nathalie Delorme,
Filip Claes,
Inge Van Hove,
Lieve Moons

Published: January 9, 2013
https://doi.org/10.1371/journal.pone.0052915

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MMP14a morphants may still have gastrulation defects

Posted by flulrich on 23 Jan 2013 at 18:11 GMT

Nice paper - minor detail, though: the authors claim there are no gastrulation defects n mmp14a morphants based on the criteria shown in figure 4D. However, that figure is concerned about defects in epiboly rather than body axis extension. An in situ for no tail, hgg1 and dlx4 would show whether there are migration defects of the prechordal plate or convergent extension defects of the axial mesoderm.
However, this is not really relevant to the rest of the paper, which has beautiful neuronal pictures and nice in situs, among others. Thanks for publishing!

No competing interests declared.

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Matrix Metalloproteinase 14 in the Zebrafish: An Eye on Retinal and Retinotectal Development

Matrix Metalloproteinase 14 in the Zebrafish: An Eye on Retinal and Retinotectal Development

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MMP14a morphants may still have gastrulation defects

Posted by flulrich on 23 Jan 2013 at 18:11 GMT