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Research Article

Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response

  • David S. Terman equal contributor mail,

    equal contributor Contributed equally to this work with: David S. Terman, Benjamin L. Viglianti

    dst@sbcglobal.net (DST); mark.dewhirst@duke.edu (MWD)

    Affiliation: Molecular Genetics Program, Jenomic, Carmel, California, United States of America

    These authors also contributed equally to this work.

    X
  • Benjamin L. Viglianti equal contributor,

    equal contributor Contributed equally to this work with: David S. Terman, Benjamin L. Viglianti

    Affiliation: Department of Radiology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Rahima Zennadi,

    Affiliation: Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Diane Fels,

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Richard J. Boruta,

    Affiliation: Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Hong Yuan,

    Affiliation: Department of Radiology, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Mathew R. Dreher,

    Affiliation: National Institutes of Health, Clinical Center, Diagnostic Radiology Department, Bethesda, Maryland, United States of America

    X
  • Gerald Grant,

    Affiliation: Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Zahid N. Rabbani,

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Ejung Moon,

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Lan Lan,

    Affiliation: Department of Biostatistics, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Joseph Eble,

    Affiliation: Department of Radiology, Mayo Clinic Foundation, Rochester, Minnesota, United States of America

    X
  • Yiting Cao,

    Affiliation: Department of Surgery, Division of Neurooncology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Brian Sorg,

    Affiliation: Cancer Diagnosis Program, National Cancer Institute, Bethesda, Maryland, United States of America

    X
  • Kathleen Ashcraft,

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Greg Palmer,

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Marilyn J. Telen,

    Affiliation: Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Mark W. Dewhirst mail

    dst@sbcglobal.net (DST); mark.dewhirst@duke.edu (MWD)

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

    These authors also contributed equally to this work.

    X
  • Published: January 09, 2013
  • DOI: 10.1371/journal.pone.0052543

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Media Coverage of This Article

Posted by PLoS_ONE_Group on 14 Jan 2013 at 17:55 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Eureka Alert
Title: “Genetic form of anemia offers new avenue to treating drug-resistant tumors”
http://www.eurekalert.org...

Publication: Market Watch
Title: “Genetic Form of Anemia Offers New Avenue to Treating Drug-resistant Tumors - MarketWatch”
http://www.marketwatch.co...

Publication: Science Codex
Title: “Sickle cells show potential to attack aggressive cancer tumors | Science Codex”
http://www.sciencecodex.c...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

RE: Media Coverage of This Article

PLoS_ONE_Group replied to PLoS_ONE_Group on 18 Jan 2013 at 23:28 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Science Codex
Title: “Genetic form of anemia offers new avenue to treating drug-resistant tumors | Science Codex”
http://www.sciencecodex.c...

Publication: EveryONE PLoS ONE Community Blog
Title: “Targeting Drug Resistant Tumors | EveryONE”
http://blogs.plos.org/eve...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

RE: RE: Media Coverage of This Article

PLoS_ONE_Group replied to PLoS_ONE_Group on 25 Jan 2013 at 23:19 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: BBC News
Title: “BBC News - Sickle-shaped blood cells 'may kill cancer cells in mice'”
http://www.bbc.co.uk/news...

Publication: Duke Chronicle
Title: “Sickle cells may be a tool against tumors | The Chronicle”
http://www.dukechronicle....

Publication: Monterey County Herald
Title: “Carmel scientist studies sickle cells as a way to fight tumors - MontereyHerald.com :”
http://www.montereyherald...

Publication: National Cancer Institute
Title: “Sickle cells show potential to attack aggressive cancer tumors - National Cancer Institute”
http://www.cancer.gov/new...

Publication: Oncology Nurse Advisor
Title: “Sickle cells target both tumor and vasculature - ONA”
http://www.oncologynursea...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff