Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response

David S. Terman; Benjamin L. Viglianti; Rahima Zennadi; Diane Fels; Richard J. Boruta; Hong Yuan; Mathew R. Dreher; Gerald Grant; Zahid N. Rabbani; Ejung Moon; Lan Lan; Joseph Eble; Yiting Cao; Brian Sorg; Kathleen Ashcraft; Greg Palmer; Marilyn J. Telen; Mark W. Dewhirst

doi:10.1371/journal.pone.0052543

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Research Article

Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response

David S. Terman ,

Contributed equally to this work with: David S. Terman, Benjamin L. Viglianti

* E-mail: dst@sbcglobal.net (DST); mark.dewhirst@duke.edu (MWD)

¶These authors also contributed equally to this work.

Affiliation Molecular Genetics Program, Jenomic, Carmel, California, United States of America
⨯
Benjamin L. Viglianti ,

Contributed equally to this work with: David S. Terman, Benjamin L. Viglianti

Affiliation Department of Radiology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Rahima Zennadi,

Affiliation Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Diane Fels,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Richard J. Boruta,

Affiliation Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Hong Yuan,

Affiliation Department of Radiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Mathew R. Dreher,

Affiliation National Institutes of Health, Clinical Center, Diagnostic Radiology Department, Bethesda, Maryland, United States of America
⨯
Gerald Grant,

Affiliation Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Zahid N. Rabbani,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Ejung Moon,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Lan Lan,

Affiliation Department of Biostatistics, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Joseph Eble,

Affiliation Department of Radiology, Mayo Clinic Foundation, Rochester, Minnesota, United States of America
⨯
Yiting Cao,

Affiliation Department of Surgery, Division of Neurooncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Brian Sorg,

Affiliation Cancer Diagnosis Program, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Kathleen Ashcraft,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Greg Palmer,

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Marilyn J. Telen,

Affiliation Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
[ ... ],
Mark W. Dewhirst

* E-mail: dst@sbcglobal.net (DST); mark.dewhirst@duke.edu (MWD)

¶These authors also contributed equally to this work.

Affiliation Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
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Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response

David S. Terman,
Benjamin L. Viglianti,
Rahima Zennadi,
Diane Fels,
Richard J. Boruta,
Hong Yuan,
Mathew R. Dreher,
Gerald Grant,
Zahid N. Rabbani,
Ejung Moon

Published: January 9, 2013
https://doi.org/10.1371/journal.pone.0052543

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 14 Jan 2013 at 17:55 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Eureka Alert
Title: “Genetic form of anemia offers new avenue to treating drug-resistant tumors”
http://www.eurekalert.org...

Publication: Market Watch
Title: “Genetic Form of Anemia Offers New Avenue to Treating Drug-resistant Tumors - MarketWatch”
http://www.marketwatch.co...

Publication: Science Codex
Title: “Sickle cells show potential to attack aggressive cancer tumors | Science Codex”
http://www.sciencecodex.c...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 18 Jan 2013 at 23:28 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Science Codex
Title: “Genetic form of anemia offers new avenue to treating drug-resistant tumors | Science Codex”
http://www.sciencecodex.c...

Publication: EveryONE PLoS ONE Community Blog
Title: “Targeting Drug Resistant Tumors | EveryONE”
http://blogs.plos.org/eve...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

RE: RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 25 Jan 2013 at 23:19 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: BBC News
Title: “BBC News - Sickle-shaped blood cells 'may kill cancer cells in mice'”
http://www.bbc.co.uk/news...

Publication: Duke Chronicle
Title: “Sickle cells may be a tool against tumors | The Chronicle”
http://www.dukechronicle....

Publication: Monterey County Herald
Title: “Carmel scientist studies sickle cells as a way to fight tumors - MontereyHerald.com :”
http://www.montereyherald...

Publication: National Cancer Institute
Title: “Sickle cells show potential to attack aggressive cancer tumors - National Cancer Institute”
http://www.cancer.gov/new...

Publication: Oncology Nurse Advisor
Title: “Sickle cells target both tumor and vasculature - ONA”
http://www.oncologynursea...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response

Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 14 Jan 2013 at 17:55 GMT

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 18 Jan 2013 at 23:28 GMT

RE: RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 25 Jan 2013 at 23:19 GMT