Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss

Madhuri S. Salker; Jaya Nautiyal; Jennifer H. Steel; Zoe Webster; Sandra Šućurović; Marilena Nicou; Yogesh Singh; Emma S. Lucas; Keisuke Murakami; Yi-Wah Chan; Sean James; Yazan Abdallah; Mark Christian; B. Anne Croy; Biserka Mulac-Jericevic; Siobhan Quenby; Jan J. Brosens

doi:10.1371/journal.pone.0052252

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Peer-reviewed

Research Article

Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss

Madhuri S. Salker,

Affiliations Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom
⨯
Jaya Nautiyal,

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom
⨯
Jennifer H. Steel,

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom
⨯
Zoe Webster,

Affiliation Embryonic Stem Cell Facility, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, United Kingdom
⨯
Sandra Šućurović,

Affiliations Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom, Department of Physiology and Immunology, Medical School, University of Rijeka, Rijeka, Croatia
⨯
Marilena Nicou,

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom
⨯
Yogesh Singh,

Affiliation Department of Infection and Immunity, The Royal Veterinary College, Royal College Street, London, United Kingdom
⨯
Emma S. Lucas,

Affiliation Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom
⨯
Keisuke Murakami,

Affiliation Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom
⨯
Yi-Wah Chan,

Affiliation Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom
⨯
Sean James,

Affiliation Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom
⨯
Yazan Abdallah,

Affiliation Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom
⨯
Mark Christian,

Affiliation Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom
⨯
B. Anne Croy,

Affiliation Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada
⨯
Biserka Mulac-Jericevic,

Affiliation Department of Physiology and Immunology, Medical School, University of Rijeka, Rijeka, Croatia
⨯
Siobhan Quenby,

Affiliation Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom
⨯
[ ... ],
Jan J. Brosens

* E-mail: J.J.Brosens@warwick.ac.uk

Affiliation Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom
⨯
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Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss

Madhuri S. Salker,
Jaya Nautiyal,
Jennifer H. Steel,
Zoe Webster,
Sandra Šućurović,
Marilena Nicou,
Yogesh Singh,
Emma S. Lucas,
Keisuke Murakami,
Yi-Wah Chan

Published: December 27, 2012
https://doi.org/10.1371/journal.pone.0052252

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Media Coverage of this Article

Posted by PLOS_ONE_Group on 04 Jan 2013 at 22:20 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Daily Mail
Title: “Scientists discover why some women suffer repeated miscarriages | Mail Online”
http://www.dailymail.co.u...

Publication: Imperial College London
Title: “Scientists pinpoint molecular signals that make some women prone to miscarriage”
http://www3.imperial.ac.u...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

RE: Media Coverage of this Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 14 Jan 2013 at 17:53 GMT

Publication: Press Release
Title: “PressZoom.com - Global News Service - News and Press Release Distribution”
http://presszoom.com/stor...

Publication: Scientist Live
Title: “Scientists Pinpoint Molecular Signals That Make Some Women Prone To Miscarriage - Medical And Biological - an eFood Article at Scientist Live”
http://www.scientistlive....

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss

Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss

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Media Coverage of this Article

Posted by PLOS_ONE_Group on 04 Jan 2013 at 22:20 GMT

RE: Media Coverage of this Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 14 Jan 2013 at 17:53 GMT