Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens

Dominick J. Laddy; Jian Yan; Michele Kutzler; Darwyn Kobasa; Gary P. Kobinger; Amir S. Khan; Jack Greenhouse; Niranjan Y. Sardesai; Ruxandra Draghia-Akli; David B. Weiner

doi:10.1371/journal.pone.0002517

Loading metrics

Open Access

Peer-reviewed

Research Article

Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens

Dominick J. Laddy,

Affiliation Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Jian Yan,

Affiliation Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Michele Kutzler,

Affiliation Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Darwyn Kobasa,

Affiliation Respiratory Viruses, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Gary P. Kobinger,

Affiliations Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
⨯
Amir S. Khan,

Affiliation VGX Pharmaceuticals, Blue Bell, Pennsylvania, United States of America
⨯
Jack Greenhouse,

Affiliation Bioqual, Inc., Rockville, Maryland, United States of America
⨯
Niranjan Y. Sardesai,

Affiliation VGX Pharmaceuticals, Blue Bell, Pennsylvania, United States of America
⨯
Ruxandra Draghia-Akli,

Affiliation VGX Pharmaceuticals, Blue Bell, Pennsylvania, United States of America
⨯
David B. Weiner

* E-mail: dbweiner@mail.med.upenn.edu

Affiliation Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens

Dominick J. Laddy,
Jian Yan,
Michele Kutzler,
Darwyn Kobasa,
Gary P. Kobinger,
Amir S. Khan,
Jack Greenhouse,
Niranjan Y. Sardesai,
Ruxandra Draghia-Akli,
David B. Weiner

Published: June 25, 2008
https://doi.org/10.1371/journal.pone.0002517

Reader Comments

Post a new comment on this article

Publisher's Note: Correction to Author Contributions

Posted by PLOS_ONE_Group on 15 Jul 2008 at 01:09 GMT

Atlanta, GA).
http://plosone.org/article/info:doi/10.1371/journal.pone.0002517#article1.back1.ack1.p1

The Author Contributions are incorrect. They should read: "Conceived and designed the experiments: DW JY DL. Performed the experiments: DW GK MK JY DK JG DL. Analyzed the data: DW JY DL. Contributed reagents/materials/analysis tools: DW AK NS RD. Wrote the paper: DW RD DL."

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Influenza
Is the Subject Area "Influenza" applicable to this article?

Thanks for your feedback.
Viral vaccines
Is the Subject Area "Viral vaccines" applicable to this article?

Thanks for your feedback.
Ferrets
Is the Subject Area "Ferrets" applicable to this article?

Thanks for your feedback.
Immune response
Is the Subject Area "Immune response" applicable to this article?

Thanks for your feedback.
H5N1
Is the Subject Area "H5N1" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Antibodies
Is the Subject Area "Antibodies" applicable to this article?

Thanks for your feedback.
Macaque
Is the Subject Area "Macaque" applicable to this article?

Thanks for your feedback.

Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens

Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Publisher's Note: Correction to Author Contributions

Posted by PLOS_ONE_Group on 15 Jul 2008 at 01:09 GMT