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Research Article

Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

  • A. David Smith equal contributor mail,

    equal contributor Contributed equally to this work with: A. David Smith, Helga Refsum

    david.smith@pharm.ox.ac.uk

    Affiliations: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom, University Department of Pharmacology and Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

    X
  • Stephen M. Smith,

    Affiliation: Department of Clinical Neurology, Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, United Kingdom

    X
  • Celeste A. de Jager,

    Affiliation: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

    X
  • Philippa Whitbread,

    Affiliation: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

    X
  • Carole Johnston,

    Affiliations: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom, University Department of Pharmacology and Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

    X
  • Grzegorz Agacinski,

    Affiliation: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

    X
  • Abderrahim Oulhaj,

    Affiliation: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

    X
  • Kevin M. Bradley,

    Affiliation: Department of Radiology and Nuclear Medicine, Oxford Radcliffe Hospitals NHS Trust, Oxford, United Kingdom

    X
  • Robin Jacoby,

    Affiliation: University Department of Psychiatry, University of Oxford, Oxford, United Kingdom

    X
  • Helga Refsum equal contributor

    equal contributor Contributed equally to this work with: A. David Smith, Helga Refsum

    Affiliations: Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom, University Department of Pharmacology and Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

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  • Published: September 08, 2010
  • DOI: 10.1371/journal.pone.0012244

Reader Comments (3)

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Media Coverage of This Article

Posted by PLoS_ONE_Group on 02 Sep 2011 at 15:01 GMT

The following articles represent some of the media coverage that has occurred for this paper:

Publication: Trust The Evidence
Title: “Alzheimer’s and vitamin B - Intention to treat, often not understood | TrustTheEvidence.net”
http://blogs.trusttheevid...

Publication: Evidence Matters
Title: “David Smith, B vitamins and Alzheimer's Disease - Evidence Matters' posterous”
http://evidencematters.po...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

RE: Media Coverage of This Article

adspharm replied to PLoS_ONE_Group on 20 Sep 2011 at 12:46 GMT

I am very surprised that members of PLoSONE staff are posting such comments on a paper accepted by the Editors for publication. The links in this comment were initially posted on blogs a year ago when the paper was first published and at that time the authors responded to the technical comments by Carl Heneghan. The comment now posted does not contain our reply. It was clear that Dr Heneghan had not read our paper properly and he did post our reply at the time. So why is a member of the PLoSONE staff now, one year later, making the same mistake? More important, why does the journal permit a staff member publically to insinuate that a paper already published in the journal may be at fault and that the authors are possibly dishonest, without presenting any evidence. Finally, I consider it in principle a bad policy that comments like this can be posted anonymously.
David Smith david.smith@pharm.ox.ac.uk

No competing interests declared.

RE: Media Coverage of This Article

MattJHodgkinson replied to adspharm on 20 Sep 2011 at 14:52 GMT

The links to these blog posts were posted as part of the PLoS ONE media tracking project, which aims to link to media and blog coverage that articles have received. Please see http://blogs.plos.org/eve... for more details.

Dr Smith's response to Carl Henaghan is here: http://blogs.trusttheevid...

NHS Choices' "Behind the Headlines" also covered this paper: http://www.nhs.uk/news/20...

Other media coverage can be found in the LA Times (http://articles.latimes.c...), CBC News (http://www.cbc.ca/news/he...), WebMD (http://www.webmd.com/brai...), and Reuters (http://uk.reuters.com/art...).

Another blog by William Yates is here: http://brainposts.blogspo...

Competing interests declared: I am an Associate Editor for PLoS ONE.

RE: Media Coverage of This Article

PLoS_ONE_Group replied to PLoS_ONE_Group on 06 Apr 2012 at 22:10 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Dynamic Chiropractic
Title: “B Vitamins Slow Brain Aging, Preserve Cognitive Function in Older Patients”
http://www.dynamicchiropr...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

RE: RE: Media Coverage of This Article

PLoS_ONE_Group replied to PLoS_ONE_Group on 17 Nov 2012 at 00:12 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: NHS Choices
Title: “Vitamin B12 may prevent the brain shrinkage behind some dementia - Health News - NHS Choices”
http://www.nhs.uk/news/20...

Publication: NHS Choices
Title: “Can vitamin B pills prevent Alzheimer's? - Health News - NHS Choices”
http://www.nhs.uk/news/20...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

RE: RE: RE: Media Coverage of This Article

PLoS_ONE_Group replied to PLoS_ONE_Group on 07 Dec 2012 at 21:58 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Science Media Centre Australia
Title: “RAPID ROUNDUP: Vitamin B and Alzheimer's disease “ experts respond “ AusSMC - Australian Science Media Centre”
http://www.smc.org.au/201...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff