A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia

Eliot B. Friedman; Yi Sun; Jason T. Moore; Hsiao-Tung Hung; Qing Cheng Meng; Priyan Perera; William J. Joiner; Steven A. Thomas; Roderic G. Eckenhoff; Amita Sehgal; Max B. Kelz

doi:10.1371/journal.pone.0011903

Loading metrics

Open Access

Peer-reviewed

Research Article

A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia

Eliot B. Friedman,

Affiliations Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Yi Sun,

Affiliation Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Jason T. Moore,

Affiliations Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Hsiao-Tung Hung,

Affiliations Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Qing Cheng Meng,

Affiliation Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Priyan Perera,

Affiliation Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
William J. Joiner,

Current address: Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Affiliation Howard Hughes Medical Institute, Philadelphia, Pennsylvania, United States of America
⨯
Steven A. Thomas,

Affiliation Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Roderic G. Eckenhoff,

Affiliation Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Amita Sehgal,

Affiliations Howard Hughes Medical Institute, Philadelphia, Pennsylvania, United States of America, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Max B. Kelz

* E-mail: kelzma@uphs.upenn.edu

Affiliations Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia

Eliot B. Friedman,
Yi Sun,
Jason T. Moore,
Hsiao-Tung Hung,
Qing Cheng Meng,
Priyan Perera,
William J. Joiner,
Steven A. Thomas,
Roderic G. Eckenhoff,
Amita Sehgal

Published: July 30, 2010
https://doi.org/10.1371/journal.pone.0011903

Reader Comments

Post a new comment on this article

Media Coverage of This Article

Posted by PLOS_ONE_Group on 02 Mar 2012 at 22:35 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Scientific American
Title: “What Doctors Don't Understand about Anesthesia: Scientific American”
http://www.scientificamer...

Publication: Becker's ASC Review
Title: “Study: Brain Resists Emergence From Anesthesia”
http://www.beckersasc.com...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

RE: Media Coverage of This Article

Kelz replied to PLOS_ONE_Group on 03 Mar 2012 at 02:05 GMT

http://www.huffingtonpost...

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Anesthetics
Is the Subject Area "Anesthetics" applicable to this article?

Thanks for your feedback.
Inertia
Is the Subject Area "Inertia" applicable to this article?

Thanks for your feedback.
Anesthesia
Is the Subject Area "Anesthesia" applicable to this article?

Thanks for your feedback.
Drosophila melanogaster
Is the Subject Area "Drosophila melanogaster" applicable to this article?

Thanks for your feedback.
Sleep
Is the Subject Area "Sleep" applicable to this article?

Thanks for your feedback.
Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Pharmacokinetics
Is the Subject Area "Pharmacokinetics" applicable to this article?

Thanks for your feedback.
Evolutionary emergence
Is the Subject Area "Evolutionary emergence" applicable to this article?

Thanks for your feedback.

A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia

A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Media Coverage of This Article

Posted by PLOS_ONE_Group on 02 Mar 2012 at 22:35 GMT

RE: Media Coverage of This Article

Kelz replied to PLOS_ONE_Group on 03 Mar 2012 at 02:05 GMT