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Research Article

Phase I Randomized Safety Study of Twice Daily Dosing of Acidform Vaginal Gel: Candidate Antimicrobial Contraceptive

  • Marla J. Keller mail,

    marla.keller@einstein.yu.edu

    Affiliations: Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America, Departments of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America

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  • Colleen A. Carpenter,

    Affiliation: Department of Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America

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  • Yungtai Lo,

    Affiliation: Departments of Epidemiology and Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America

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  • Mark H. Einstein,

    Affiliations: Departments of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America, Departments of Epidemiology and Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America

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  • Congzhou Liu,

    Affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • David N. Fredricks,

    Affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Betsy C. Herold

    Affiliations: Departments of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America, Department of Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America, Departments of Microbiology and Immunology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America

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  • Published: October 08, 2012
  • DOI: 10.1371/journal.pone.0046901

Reader Comments (1)

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Polymers or other ingredients causing irritation?

Posted by vishand on 16 Oct 2012 at 23:04 GMT

Interesting results. If I get the article correctly, the irritation is attributed to the polymer in the Gel. Is it possible for authors to comment on why they believe the irritation is a result of polymer and not a response to preservative and other ingredients within the Acidform Gel?

No competing interests declared.

RE: Polymers or other ingredients causing irritation?

makeller replied to vishand on 22 Oct 2012 at 01:26 GMT

The irritation could be due to any of the multiple ingredients present in the gel, including the acidic compounds, the preservative, the polymer thickeners or glycerin.

No competing interests declared.