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Research Article

Quantifying the Clinical Significance of Cannabis Withdrawal

  • David J. Allsop mail,

    d.allsop@unsw.edu.au

    Affiliation: National Cannabis Prevention and Information Centre, National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia

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  • Jan Copeland,

    Affiliation: National Cannabis Prevention and Information Centre, National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia

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  • Melissa M. Norberg,

    Affiliation: National Cannabis Prevention and Information Centre, National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia

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  • Shanlin Fu,

    Affiliation: Centre for Forensic Science, School of Chemistry and Forensic Science, University of Technology Sydney (UTS), New South Wales, Australia

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  • Anna Molnar,

    Affiliation: Centre for Forensic Science, School of Chemistry and Forensic Science, University of Technology Sydney (UTS), New South Wales, Australia

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  • John Lewis,

    Affiliation: Centre for Forensic Science, School of Chemistry and Forensic Science, University of Technology Sydney (UTS), New South Wales, Australia

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  • Alan J. Budney

    Affiliation: Geisel School of Medicine at Dartmouth, Hanover, Lebanon, New Hampshire, United States of America

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  • Published: September 26, 2012
  • DOI: 10.1371/journal.pone.0044864

Reader Comments (4)

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Participant Requirement

Posted by Botticelli on 28 Sep 2012 at 03:58 GMT

(c) previous experience of at least one cannabis withdrawal symptom
http://plosone.org/article/info:doi/10.1371/journal.pone.0044864#article1.body1.sec2.sec1.p1

I'm curious to understand the purpose of the following inclusion criteria?

(c) previous experience of at least one cannabis withdrawal symptom

Doesn't this needlessly limit the cross section of users? It seems like it would introduce a bias toward selecting for subjects who are prone to certain withdrawal behaviors that are consistent with the hypothesis. Is there a good reason to include this selection criteria that I am not aware of?

No competing interests declared.

RE: Participant Requirement

DoobyDave replied to Botticelli on 28 Sep 2012 at 09:05 GMT

Hi, You are absolutely right, it does restrict the sample. But not needlessly. This is a study characterizing cannabis withdrawal. There would be very little point in gathering data from cannabis smokers who don't experience any withdrawal. Correct me if I'm wrong, but I think you might be getting at the cross sectional prevalence of cannabis withdrawal in ALL cannabis smokers? That would be an epidemiological prevalence study, which is quite different to this type of focused experimental investigation.

Competing interests declared: I am the lead author of the study