BRCA1/2 Mutations Appear Embryo-Lethal Unless Rescued by Low (CGG n<26) FMR1 Sub-Genotypes: Explanation for the “BRCA Paradox”?

Andrea Weghofer; Muy-Kheng Tea; David H. Barad; Ann Kim; Christian F. Singer; Klaus Wagner; Norbert Gleicher

doi:10.1371/journal.pone.0044753

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Research Article

BRCA1/2 Mutations Appear Embryo-Lethal Unless Rescued by Low (CGG n<26) FMR1 Sub-Genotypes: Explanation for the “BRCA Paradox”?

Andrea Weghofer,

Affiliations The Center for Human Reproduction, New York, New York, United States of America, Department of Gynecological Endocrinology and Reproductive Medicine, Medical University Vienna, Vienna, Austria
⨯
Muy-Kheng Tea,

Affiliation Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
⨯
David H. Barad,

Affiliations The Center for Human Reproduction, New York, New York, United States of America, Foundation for Reproductive Medicine, New York, New York, United States of America
⨯
Ann Kim,

Affiliation The Center for Human Reproduction, New York, New York, United States of America
⨯
Christian F. Singer,

Affiliation Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
⨯
Klaus Wagner,

Affiliation Department of Human Genetics, Medical University Graz, Graz, Austria
⨯
Norbert Gleicher

* E-mail: ngleicher@thechr.com

Affiliations The Center for Human Reproduction, New York, New York, United States of America, Foundation for Reproductive Medicine, New York, New York, United States of America
⨯

BRCA1/2 Mutations Appear Embryo-Lethal Unless Rescued by Low (CGG n<26) FMR1 Sub-Genotypes: Explanation for the “BRCA Paradox”?

Andrea Weghofer,
Muy-Kheng Tea,
David H. Barad,
Ann Kim,
Christian F. Singer,
Klaus Wagner,
Norbert Gleicher

Published: September 12, 2012
https://doi.org/10.1371/journal.pone.0044753

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 21 Sep 2012 at 23:02 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: PR Newswire
Title: “BRCA1/2 Mutation and FMR1 Gene Study Has Potential Implications for Cancer Screening... -- NEW YORK, Sept. 12, 2012 /PRNewswire/ --”
http://www.prnewswire.com...

Publication: Center for Human Reproduction
Title: “FMR1 BRCA RESEARCH :: CHR”
http://www.centerforhuman...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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BRCA1/2 Mutations Appear Embryo-Lethal Unless Rescued by Low (CGG n<26) FMR1 Sub-Genotypes: Explanation for the “BRCA Paradox”?

BRCA1/2 Mutations Appear Embryo-Lethal Unless Rescued by Low (CGG n<26) FMR1 Sub-Genotypes: Explanation for the “BRCA Paradox”?

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Posted by PLOS_ONE_Group on 21 Sep 2012 at 23:02 GMT