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Research Article

pp32 (ANP32A) Expression Inhibits Pancreatic Cancer Cell Growth and Induces Gemcitabine Resistance by Disrupting HuR Binding to mRNAs

  • Timothy K. Williams equal contributor,

    equal contributor Contributed equally to this work with: Timothy K. Williams, Christina L. Costantino

    Affiliation: Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Christina L. Costantino equal contributor,

    equal contributor Contributed equally to this work with: Timothy K. Williams, Christina L. Costantino

    Affiliation: Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Nikolai A. Bildzukewicz,

    Affiliation: Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Nathan G. Richards,

    Affiliation: Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • David W. Rittenhouse,

    Affiliation: Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Lisa Einstein,

    Affiliation: Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Joseph A. Cozzitorto,

    Affiliation: Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Judith C. Keen,

    Affiliation: Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey, United States of America

    X
  • Abhijit Dasgupta,

    Affiliations: Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Myriam Gorospe,

    Affiliation: Laboratory of Cellular and Molecular Biology, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, Maryland, United States of America

    X
  • Gregory E. Gonye,

    Affiliation: Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Charles J. Yeo,

    Affiliations: Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Agnieszka K. Witkiewicz,

    Affiliations: Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Jonathan R. Brody mail

    Jonathan.Brody@jefferson.edu

    Affiliations: Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Published: November 29, 2010
  • DOI: 10.1371/journal.pone.0015455

Reader Comments (2)

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pp32 not a phosphatase

Posted by PatrickReilly on 04 Jan 2011 at 02:46 GMT

Just wish to note that the name pp32 is derived from "phosphoprotein" (Malek et al., 1990) not "protein phosphatase" although "PP" is used for other protein phosphatases. It would be wrong to suggest that pp32 has any known phosphatase activity.

I believe the abstract should be adjusted.

No competing interests declared.