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Research Article

Metabolome Based Reaction Graphs of M. tuberculosis and M. leprae: A Comparative Network Analysis

  • Ketki D. Verkhedkar,

    Affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India

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  • Karthik Raman,

    Affiliation: Bioinformatics Centre, Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore, India

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  • Nagasuma R. Chandra,

    Affiliation: Bioinformatics Centre, Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore, India

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  • Saraswathi Vishveshwara mail

    To whom correspondence should be addressed. E-mail: sv@mbu.iisc.ernet.in

    Affiliation: Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India

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  • Published: September 12, 2007
  • DOI: 10.1371/journal.pone.0000881

Reader Comments (1)

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Mycobacterial Metabolomics - good and worthwhile

Posted by NiyazAhmed on 11 Mar 2008 at 08:30 GMT

This excellent demonstration of the utility of mycobacterial metabolomics and its broad application in hunting possible drug targets will definitely go a long way in strengthening the academic cause of anti-infectives discovery in India. Genomic plasticity, chemical complexity and phenotypic versatility of pathogenic mycobacteria are the three interlinked forces that stratify pathogenic impacts of potentially virulent species in a biologically changing host. Our understanding of mycobacterial diversity and differential pathogenesis is based on this paradigm. However, this study surprisingly (and robustly) reveals that reductive evolution due to massive gene decay in M. leprae does not significantly affect the global structure of its metabolic circuitry.
On the other note, this paper also marks strengthening of a contemporary and most welcome trend of open access publishing adopted by the Indian Institute of Science researchers.