Increased Responsiveness of Peripheral Blood Mononuclear Cells to In Vitro TLR 2, 4 and 7 Ligand Stimulation in Chronic Pain Patients

Yuen H. Kwok; Mark R. Hutchinson; Melanie G. Gentgall; Paul E. Rolan

doi:10.1371/journal.pone.0044232

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Open Access

Peer-reviewed

Research Article

Increased Responsiveness of Peripheral Blood Mononuclear Cells to In Vitro TLR 2, 4 and 7 Ligand Stimulation in Chronic Pain Patients

Yuen H. Kwok ,

* E-mail: yuen.kwok@adelaide.edu.au

Affiliation Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia
⨯
Mark R. Hutchinson,

Affiliation Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia
⨯
Melanie G. Gentgall,

Affiliation Pain and Anaesthesia Research Clinic, University of Adelaide, Adelaide, South Australia, Australia
⨯
Paul E. Rolan

Affiliations Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia, Pain and Anaesthesia Research Clinic, University of Adelaide, Adelaide, South Australia, Australia, Pain Management Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
⨯

Increased Responsiveness of Peripheral Blood Mononuclear Cells to In Vitro TLR 2, 4 and 7 Ligand Stimulation in Chronic Pain Patients

Yuen H. Kwok,
Mark R. Hutchinson,
Melanie G. Gentgall,
Paul E. Rolan

Published: August 28, 2012
https://doi.org/10.1371/journal.pone.0044232

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Fibromyalgia

Posted by ItamGold on 01 Sep 2012 at 10:39 GMT

Do you have data on the percentage of patients with chronic pain in your research subjects that have also been diagnosis with Fibromyalgia (FM) or fulfill the diagnostic criteria for FM?
Are there any differences in the IL-1 response among females and males (even if they did not reach statistical significance)?

Sincerely,

I. Goldstein, M.D.

No competing interests declared.

RE: Fibromyalgia

YHeilieKwok replied to ItamGold on 04 Sep 2012 at 00:44 GMT

Dear Dr. Goldstein,

Thankyou for your interest. All chronic pain participant's diagnosis are presented in the supporting information table. There is 1 patient with Fibromyaglia in each of the group (CP+O and CP).

As our study was not powered to examine any gender differences in the IL-1Beta response we do not know whether there will be any differences.

Best Regards,
Yuen Kwok

No competing interests declared.

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Increased Responsiveness of Peripheral Blood Mononuclear Cells to In Vitro TLR 2, 4 and 7 Ligand Stimulation in Chronic Pain Patients

Increased Responsiveness of Peripheral Blood Mononuclear Cells to In Vitro TLR 2, 4 and 7 Ligand Stimulation in Chronic Pain Patients

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Fibromyalgia

Posted by ItamGold on 01 Sep 2012 at 10:39 GMT

RE: Fibromyalgia

YHeilieKwok replied to ItamGold on 04 Sep 2012 at 00:44 GMT