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Research Article

Developmental Trajectories of Resting EEG Power: An Endophenotype of Autism Spectrum Disorder

  • Adrienne L. Tierney mail,

    adrienne_tierney@mail.harvard.edu

    Affiliations: Harvard College Writing Program, Harvard University, Cambridge, Massachusetts, United States of America, Department of Developmental Medicine, Children’s Hospital Boston, Boston, Massachusetts, United States of America

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  • Laurel Gabard-Durnam,

    Affiliation: Department of Psychology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Vanessa Vogel-Farley,

    Affiliation: Department of Developmental Medicine, Children’s Hospital Boston, Boston, Massachusetts, United States of America

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  • Helen Tager-Flusberg,

    Affiliation: Department of Psychology, Boston University, Boston, Massachusetts, United States of America

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  • Charles A. Nelson

    Affiliations: Department of Developmental Medicine, Children’s Hospital Boston, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: June 20, 2012
  • DOI: 10.1371/journal.pone.0039127

Reader Comments (1)

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Risk/protective factor or artefact ?

Posted by Teea on 30 Jul 2012 at 15:36 GMT

I find it intriguing that across measures high-risk infants seem to converge towards "typical" values, to become indistinguishable at 24 mo. This would suggest that some of the measures taken are of protective factors that counteract the effect of early risk factors. However i wonder whether the inclusion of different numbers of infants (and different infants) at different time points does not make these conclusions premature. It is not impossible that higher rates of future ASD will be observed in those infants included later in the study. This problem is not resolved but accentuated by removing the 4 children with ASD from the later time points (because not all children included in the earlier time points had been yet assessed). Therefore what looks like a trajectory of rescue from risk may partially be a sampling artefact. I would have liked to see the data from only the participants for which all data points are available (or at least 6-18 mo data points).

No competing interests declared.