Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas

Ciaran Skerry; Jamie Harper; Mariah Klunk; William R. Bishai; Sanjay K. Jain

doi:10.1371/journal.pone.0039680

Loading metrics

Open Access

Peer-reviewed

Research Article

Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas

Ciaran Skerry,

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Jamie Harper,

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Mariah Klunk,

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
William R. Bishai,

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, KwaZulu-Natal Research Institute for Tuberculosis and HIV, Durban, South Africa, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
⨯
Sanjay K. Jain

* E-mail: sjain5@jhmi.edu

Affiliations Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas

Ciaran Skerry,
Jamie Harper,
Mariah Klunk,
William R. Bishai,
Sanjay K. Jain

Published: June 27, 2012
https://doi.org/10.1371/journal.pone.0039680

Reader Comments

Post a new comment on this article

Media Coverage of This Article

Posted by PLOS_ONE_Group on 29 Jun 2012 at 17:48 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Newswise
Title: “TB Treatment Paradox: Mouse Studies Show Body's Own Response Helps TB Bacteria Survive”
http://www.newswise.com/a...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Tuberculosis
Is the Subject Area "Tuberculosis" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Mycobacterium tuberculosis
Is the Subject Area "Mycobacterium tuberculosis" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Cytokine therapy
Is the Subject Area "Cytokine therapy" applicable to this article?

Thanks for your feedback.
Multi-drug-resistant tuberculosis
Is the Subject Area "Multi-drug-resistant tuberculosis" applicable to this article?

Thanks for your feedback.
Granulomas
Is the Subject Area "Granulomas" applicable to this article?

Thanks for your feedback.

Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas

Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Media Coverage of This Article

Posted by PLOS_ONE_Group on 29 Jun 2012 at 17:48 GMT