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Research Article

Urinary Copper Elevation in a Mouse Model of Wilson's Disease Is a Regulated Process to Specifically Decrease the Hepatic Copper Load

  • Lawrence W. Gray,

    Affiliation: Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

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  • Fangyu Peng,

    Affiliation: Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Shannon A. Molloy,

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Venkata S. Pendyala,

    Affiliation: Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

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  • Abigael Muchenditsi,

    Affiliation: Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

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  • Otto Muzik,

    Affiliation: Carman and Ann Adams Department of Pediatrics and Department of Radiology, Wayne State University, School of Medicine, Detroit, Michigan, United States of America

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  • Jaekwon Lee,

    Affiliation: Redox Biology Center, Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, United States of America

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  • Jack H. Kaplan,

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America

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  • Svetlana Lutsenko mail

    lutsenko@jhmi.edu

    Affiliation: Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America

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  • Published: June 22, 2012
  • DOI: 10.1371/journal.pone.0038327

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Posted by LawrenceGray on 28 Jun 2012 at 20:37 GMT

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Competing interests declared: I am the First author