Small Molecules with Similar Structures Exhibit Agonist, Neutral Antagonist or Inverse Agonist Activity toward Angiotensin II Type 1 Receptor

Shin-ichiro Miura; Yoshihiro Kiya; Hiroyuki Hanzawa; Naoki Nakao; Masahiro Fujino; Satoshi Imaizumi; Yoshino Matsuo; Hiroaki Yanagisawa; Hiroyuki Koike; Issei Komuro; Sadashiva S. Karnik; Keijiro Saku

doi:10.1371/journal.pone.0037974

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Open Access

Peer-reviewed

Research Article

Small Molecules with Similar Structures Exhibit Agonist, Neutral Antagonist or Inverse Agonist Activity toward Angiotensin II Type 1 Receptor

Shin-ichiro Miura ,

Contributed equally to this work with: Shin-ichiro Miura, Yoshihiro Kiya

* E-mail: miuras@cis.fukuoka-u.ac.jp

Affiliations Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan, Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, United States of America
⨯
Yoshihiro Kiya ,

Contributed equally to this work with: Shin-ichiro Miura, Yoshihiro Kiya

Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
⨯
Hiroyuki Hanzawa,

Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan
⨯
Naoki Nakao,

Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan
⨯
Masahiro Fujino,

Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
⨯
Satoshi Imaizumi,

Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
⨯
Yoshino Matsuo,

Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
⨯
Hiroaki Yanagisawa,

Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan
⨯
Hiroyuki Koike,

Affiliation Research & Development Division, Daiichi Sankyo Company, Ltd., Tokyo, Japan
⨯
Issei Komuro,

Affiliation Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
⨯
Sadashiva S. Karnik,

Affiliation Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, United States of America
⨯
Keijiro Saku

Affiliation Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
⨯

Small Molecules with Similar Structures Exhibit Agonist, Neutral Antagonist or Inverse Agonist Activity toward Angiotensin II Type 1 Receptor

Shin-ichiro Miura,
Yoshihiro Kiya,
Hiroyuki Hanzawa,
Naoki Nakao,
Masahiro Fujino,
Satoshi Imaizumi,
Yoshino Matsuo,
Hiroaki Yanagisawa,
Hiroyuki Koike,
Issei Komuro

Published: June 14, 2012
https://doi.org/10.1371/journal.pone.0037974

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Congratulations

Posted by jedsrose on 25 Jun 2012 at 11:24 GMT

Thank you all authors for the attempt to use molecular biology techniques in order to show "molecular biologists" that DNA is quite different from proteins. Despite the fact that I do not believe they will be convinced. They seems to be short in scientific rigor. For them, chemistry in biology is no longer required, DNA DOES it all.

No competing interests declared.

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Small Molecules with Similar Structures Exhibit Agonist, Neutral Antagonist or Inverse Agonist Activity toward Angiotensin II Type 1 Receptor

Small Molecules with Similar Structures Exhibit Agonist, Neutral Antagonist or Inverse Agonist Activity toward Angiotensin II Type 1 Receptor

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Congratulations

Posted by jedsrose on 25 Jun 2012 at 11:24 GMT