Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Steven D. Kunkel; Christopher J. Elmore; Kale S. Bongers; Scott M. Ebert; Daniel K. Fox; Michael C. Dyle; Steven A. Bullard; Christopher M. Adams

doi:10.1371/journal.pone.0039332

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Research Article

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Steven D. Kunkel,

Affiliations Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America
⨯
Christopher J. Elmore,

Affiliation Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Kale S. Bongers,

Affiliation Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Scott M. Ebert,

Affiliation Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Daniel K. Fox,

Affiliation Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Michael C. Dyle,

Affiliation Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Steven A. Bullard,

Affiliation Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America
⨯
Christopher M. Adams

* E-mail: christopher-adams@uiowa.edu

Affiliations Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America
⨯

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Steven D. Kunkel,
Christopher J. Elmore,
Kale S. Bongers,
Scott M. Ebert,
Daniel K. Fox,
Michael C. Dyle,
Steven A. Bullard,
Christopher M. Adams

Published: June 20, 2012
https://doi.org/10.1371/journal.pone.0039332

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 22 Jun 2012 at 23:50 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Belfast Telegraph
Title: “Apples could help 'peel' off the weight - Food & Drink, Life & Style - Belfasttelegraph.co.uk”
http://www.belfasttelegra...

Publication: Bernama
Title: “BERNAMA - Apple Peel Compound Reduces Obesity In Mice: Study”
http://www.bernama.com/be...

Publication: Best Syndication
Title: “Ursolic Acid found in an Apple Peel may increase the amount of Calories Burned | Best Syndication”
http://www.bestsyndicatio...

Publication: Daily Mail
Title: “How apple skin's waxy sheen could help slimmers peel off the weight | Mail Online”
http://www.dailymail.co.u...

Publication: Emax Health
Title: “Dieters, Think Before You Peel That Apple”
http://www.emaxhealth.com...

Publication: Express
Title: “Express.co.uk - Home of the Daily and Sunday Express | UK News :: Why an apple a day really can keep the doctor away”
http://www.express.co.uk/...

Publication: Glamour
Title: “The Surprising Fruit That May Keep You Slim (And You Have it in Your Kitchen Right Now): Vitamin G: Health & Fitness: glamour.com”
http://www.glamour.com/he...

Publication: Hindustan Times
Title: “Apple compound may help burn fat, reduce obesity - Hindustan Times”
http://www.hindustantimes...

Publication: Huffington Post UK
Title: “Apple Peel Compound Ursolic Acid Boosts Calorie Burning, Reduces Obesity In Mice”
http://www.huffingtonpost...

Publication: International Science Times
Title: “Calorie Burning Compound in Apple Peel Reduces Obesity in Mice - International Science Times”
http://www.isciencetimes....

Publication: Medical Daily
Title: “Apple Peel, New Weapon to Fight Obesity - Medical Daily”
http://www.medicaldaily.c...

Publication: New Zealand Herald
Title: “Apple peel could help battle bulge: study - Health - NZ Herald News”
http://www.nzherald.co.nz...

Publication: Pacific Standard
Title: “Apples: An Anti-Obesity Pill? -”
http://www.psmag.com/heal...

Publication: Top News United States
Title: “Apple a Day Can Help You Burn Calories | TopNews United States”
http://topnews.us/content...

Publication: Xinhua
Title: “Apple peel compound boosts calorie burning, reduces obesity in mice: study - Xinhua | English.news.cn”
http://news.xinhuanet.com...

Publication: Zee News India
Title: “Apple compound may help burn fat, reduce obesity”
http://zeenews.india.com/...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 29 Jun 2012 at 17:38 GMT

The following articles represent some of the media coverage that has occurred for this paper:

Publication: NutraIngredients
Title: “Apple peel compound may offer obesity promise”
http://www.nutraingredien...

Publication: Earth Times
Title: “Ursolic acid found in apple peel may help fight obesity | Health | The Earth Times”
http://www.earthtimes.org...

Publication: Insidermedicine.ca
Title: “Calorie burning boosted by apple peel compound”
http://www.insidermedicin...

Publication: firstcoastnews.com
Title: “Are apples the next fad diet? | firstcoastnews.com”
http://www.firstcoastnews...

Publication: Press citizen.com
Title: “UI study: Compound found in apple peel reduces obesity in mice | Iowa City Press Citizen | press-citizen.com”
http://www.press-citizen....

Publication: Health.india.com
Title: “Apple compound helps burn fat! | Health News | Health Research | Diet & Weight Loss Tips| Health Products | Medicines & Drugs | Health.India.com”
http://health.india.com/n...

Publication: Everyday Health
Title: “Can an Apple a Day Keep Obesity Away? - Weight Center - Everyday Health”
http://www.everydayhealth...

Publication: Fox News
Title: “Apple peel compound may help ward off obesity | Fox News”
http://www.foxnews.com/he...

Publication: Your Olive Branch News
Title: “Apple Skin | Your Olive Branch News - yobo”
http://news.yourolivebran...

Publication: Times of India
Title: “An apple peel a day keeps fat away - Times Of India”
http://articles.timesofin...

Publication: Business Review India
Title: “Apple peel ingredient fights obesity - Business Review India”
http://www.businessreview...

Publication: The National
Title: “An apple a day may keep obesity away - The National”
http://www.thenational.ae...

Publication: Science 2.0
Title: “Ursolic Acid: Apple Peel Compound Reduces Obesity In Mice”
http://www.science20.com/...

Publication: Fresh Plaza
Title: “US: Apples could help against obesity”
http://www.freshplaza.com...

Publication: TODAY Health
Title: “An apple a day may help fight obesity - TODAY Health”
http://todayhealth.today....

Publication: French Tribune
Title: “Apple Peel Can Heal Obesity, Says Study | French Tribune”
http://frenchtribune.com/...

Publication: The Daily Meal
Title: “An Apple Peel a Day Could Keep Obesity at Bay | The Daily Meal”
http://www.thedailymeal.c...

Publication: Hive Health Media
Title: “Can Eating Apple Peels Reduce Obesity Risks?”
http://www.hivehealthmedi...

Publication: HelpingYouCare
Title: “Compound in Apples May Help Build Muscles & Fight Obesity and Diabetes, New Study Suggests | HelpingYouCare™”
http://www.helpingyoucare...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

RE: RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 06 Jul 2012 at 21:33 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Wall Street Journal
Title: “Eating Unpeeled Apples May Keep Extra Pounds Off - WSJ.com”
http://online.wsj.com/art...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

RE: RE: RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 21 Sep 2012 at 22:59 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Liver Support
Title: “Keep Your Liver Lean with Apple Skin”
http://www.liversupport.c...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLOS ONE Staff

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Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 22 Jun 2012 at 23:50 GMT

RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 29 Jun 2012 at 17:38 GMT

RE: RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 06 Jul 2012 at 21:33 GMT

RE: RE: RE: Media Coverage of This Article

PLOS_ONE_Group replied to PLOS_ONE_Group on 21 Sep 2012 at 22:59 GMT