Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice

Mi-Sun Koo; Claudia Manca; Guibin Yang; Paul O'Brien; Nackmoon Sung; Liana Tsenova; Selvakumar Subbian; Dorothy Fallows; George Muller; Sabine Ehrt; Gilla Kaplan

doi:10.1371/journal.pone.0017091

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Peer-reviewed

Research Article

Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice

Mi-Sun Koo,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Claudia Manca,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Guibin Yang,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Paul O'Brien,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Nackmoon Sung,

Affiliations Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America, National Masan Hospital Clinical Research Center, Masan City Gyeongsangnam-do, South Korea
⨯
Liana Tsenova,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Selvakumar Subbian,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Dorothy Fallows,

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
George Muller,

Affiliation Celgene Corporation, San Diego, California, United States of America
⨯
Sabine Ehrt,

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Gilla Kaplan

* E-mail: kaplangi@umdnj.edu

Affiliation Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯

Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice

Mi-Sun Koo,
Claudia Manca,
Guibin Yang,
Paul O'Brien,
Nackmoon Sung,
Liana Tsenova,
Selvakumar Subbian,
Dorothy Fallows,
George Muller,
Sabine Ehrt

Published: February 25, 2011
https://doi.org/10.1371/journal.pone.0017091

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Roflumilast

Posted by SALUJA on 06 May 2011 at 21:05 GMT

Would roflumilast have done the same job?

No competing interests declared.

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Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice

Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice

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Roflumilast

Posted by SALUJA on 06 May 2011 at 21:05 GMT