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Research Article

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

  • Steven D. Kunkel,

    Affiliations: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America

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  • Christopher J. Elmore,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Kale S. Bongers,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Scott M. Ebert,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Daniel K. Fox,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Michael C. Dyle,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Steven A. Bullard,

    Affiliation: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

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  • Christopher M. Adams mail

    christopher-adams@uiowa.edu

    Affiliations: Departments of Internal Medicine and Molecular Physiology and Biophysics, and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States of America

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  • Published: June 20, 2012
  • DOI: 10.1371/journal.pone.0039332

Reader Comments (2)

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This could be due to Increased Testosterone Caused by Ursolic Acid

Posted by jamesmhoward on 22 Jun 2012 at 11:54 GMT

A case may be made that ursolic acid increases testosterone. I suggest the positive effects of skeletal muscle stimulation induced by ursolic acid reported in KunKel, et al., may be due to increased testosterone levels.

No competing interests declared.