Accumulation of an Antidepressant in Vesiculogenic Membranes of Yeast Cells Triggers Autophagy

Jingqiu Chen; Daniel Korostyshevsky; Sean Lee; Ethan O. Perlstein

doi:10.1371/journal.pone.0034024

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Peer-reviewed

Research Article

Accumulation of an Antidepressant in Vesiculogenic Membranes of Yeast Cells Triggers Autophagy

Jingqiu Chen ,

Contributed equally to this work with: Jingqiu Chen, Daniel Korostyshevsky

Affiliation Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
⨯
Daniel Korostyshevsky ,

Contributed equally to this work with: Jingqiu Chen, Daniel Korostyshevsky

Affiliation Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
⨯
Sean Lee,

Affiliation Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
⨯
Ethan O. Perlstein

* E-mail: eperlste@princeton.edu

Affiliation Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
⨯

Accumulation of an Antidepressant in Vesiculogenic Membranes of Yeast Cells Triggers Autophagy

Jingqiu Chen,
Daniel Korostyshevsky,
Sean Lee,
Ethan O. Perlstein

Published: April 18, 2012
https://doi.org/10.1371/journal.pone.0034024

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Membrane Medicine

Posted by gpabst on 05 Jun 2012 at 09:29 GMT

Congrats to this interesting article. It clearly shows that drugs may accumulate in certain membranes and lead to physiological consequences possibly through secondary membrane mediated effects.
It would be interesting to know the membrane partitioning coefficients of sertraline in different lipid environments. Electrostatic interactions are important, but hydrophobic forces etc. as well. "All together" determine the location of the drug within the membrane.
Anyway it goes to show that direct drug-receptor interactions is not the last word in wisdom for drug development.

No competing interests declared.

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Accumulation of an Antidepressant in Vesiculogenic Membranes of Yeast Cells Triggers Autophagy

Accumulation of an Antidepressant in Vesiculogenic Membranes of Yeast Cells Triggers Autophagy

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Membrane Medicine

Posted by gpabst on 05 Jun 2012 at 09:29 GMT