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Research Article

Adverse Metabolic Response to Regular Exercise: Is It a Rare or Common Occurrence?

  • Claude Bouchard mail,

    claude.bouchard@pbrc.edu

    Affiliation: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • Steven N. Blair,

    Affiliation: Departments of Exercise Science and Epidemiology/Biostatistics, University of South Carolina, Columbia, South Carolina, United States of America

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  • Timothy S. Church,

    Affiliation: Preventive Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • Conrad P. Earnest,

    Affiliation: Preventive Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • James M. Hagberg,

    Affiliation: Department of Kinesiology, University of Maryland, College Park, Maryland, United States of America

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  • Keijo Häkkinen,

    Affiliation: Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland

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  • Nathan T. Jenkins,

    Affiliation: Department of Kinesiology, University of Maryland, College Park, Maryland, United States of America

    Current address: Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, United States of America

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  • Laura Karavirta,

    Affiliation: Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland

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  • William E. Kraus,

    Affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Arthur S. Leon,

    Affiliation: School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • D. C. Rao,

    Affiliation: Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Mark A. Sarzynski,

    Affiliation: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • James S. Skinner,

    Affiliation: Professor Emeritus of Kinesiology, Indiana University, Bloomington, Indiana, United States of America

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  • Cris A. Slentz,

    Affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Tuomo Rankinen

    Affiliation: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America

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  • Published: May 30, 2012
  • DOI: 10.1371/journal.pone.0037887

Reader Comments (13)

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My reactions

Posted by CMH1 on 01 Jun 2012 at 01:46 GMT

I followed the link from the NYTimes online to read this article, which I found of great interest. I do not know if my reaction to exercise is metabolic or not. However, I am not obese and while my diet is not the most perfect example, it is fairly healthy. My response to exercise is not. Even with moderate and/or nonimpact exercise, my face becomes very red and hot, I lose peripheral vision, my head pounds, and I feel as if I am going to faint. It takes a while of quite sitting to get back to normal. I have had EKGs and stress tests-- all normal. My physician's advise: don't do it if it makes you feel bad. I do hope you will continue in this work and would be eager to see you examine patient experiences as well as the lab data.

No competing interests declared.