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Research Article

Accumulation of an Antidepressant in Vesiculogenic Membranes of Yeast Cells Triggers Autophagy

  • Jingqiu Chen equal contributor,

    equal contributor Contributed equally to this work with: Jingqiu Chen, Daniel Korostyshevsky

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    X
  • Daniel Korostyshevsky equal contributor,

    equal contributor Contributed equally to this work with: Jingqiu Chen, Daniel Korostyshevsky

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    X
  • Sean Lee,

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    X
  • Ethan O. Perlstein mail

    eperlste@princeton.edu

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    X
  • Published: April 18, 2012
  • DOI: 10.1371/journal.pone.0034024

Reader Comments (16)

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Possibly related?

Posted by pilotgrrl on 18 May 2012 at 00:39 GMT

I followed this discussion from In the Pipeline. I'm not sure this is related, as the information seems self-reported, and therefore anecdotal. The sample size is quite small, as well. The reference is from a study published in the Canadian Journal of Psychology about the rare side effect of yawning as a cause of orgasm in female study patients taking clomipramine, which can be found at the link below.

http://baillement.com/clo...

No competing interests declared.

RE: Possibly related?

eperlste replied to pilotgrrl on 18 May 2012 at 13:18 GMT

Thanks for posting. I'm not a medical doctor, so I have zero clinical insight on this matter.

However, apparently the yawning part of the side effect appears to be conserved in rodents: http://www.ncbi.nlm.nih.g... ("Desipramine induces yawning behaviour in rats.")

No competing interests declared.